Genome-wide association mapping of the architecture of susceptibility to the root-knot nematode Meloidogyne incognita in Arabidopsis thaliana

The New Phytologist
Sonja WarmerdamGeert Smant

Abstract

Susceptibility to the root-knot nematode Meloidogyne incognita in plants is thought to be a complex trait based on multiple genes involved in cell differentiation, growth and defence. Previous genetic analyses of susceptibility to M. incognita have mainly focused on segregating dominant resistance genes in crops. It is not known if plants harbour significant genetic variation in susceptibility to M. incognita independent of dominant resistance. To study the genetic architecture of susceptibility to M. incognita, we analysed nematode reproduction on a highly diverse set of 340 natural inbred lines of Arabidopsis thaliana with genome-wide association mapping. We observed a surprisingly large variation in nematode reproduction among these lines. Genome-wide association mapping revealed four quantitative trait loci (QTLs) located on chromosomes 1 and 5 of A. thaliana significantly associated with reproductive success of M. incognita, none of which harbours typical resistance gene homologues. Mutant analysis of three genes located in two QTLs showed that the transcription factor BRASSINAZOLE RESISTANT1 and an F-box family protein may function as (co-)regulators of susceptibility to M. incognita in Arabidopsis. Our data suggest that ...Continue Reading

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Citations

Mar 12, 2019·Frontiers in Microbiology·Shweta JaiswalPratyoosh Shukla
Oct 17, 2019·Frontiers in Plant Science·Kazuki SatoKen Shirasu
Jan 21, 2021·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jean Carlos AlekcevetchFrancismar Correa Marcelino-Guimarães
May 2, 2021·Current Opinion in Biotechnology·Sebastian Eves-van den AkkerGodelieve Gheysen
Jul 5, 2021·Current Opinion in Biotechnology·Sapinder BaliCynthia Gleason

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Methods Mentioned

BETA
PCR
electrophoresis
dissection
reverse transcription PCR
confocal microscopy
transgenic
glycosylase

Software Mentioned

ImageJ
rrBLUP
R
REML
R hizo package

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