Genome-wide association mapping with longitudinal data.

Genetic Epidemiology
Nicholas A FurlotteSusana Eyheramendy

Abstract

Many genome-wide association studies have been performed on population cohorts that contain phenotype measurements at multiple time points. However, standard association methodologies only consider one time point. In this paper, we propose a mixed-model-based approach for performing association mapping which utilizes multiple phenotype measurements for each individual. We introduce an analytical approach to calculate statistical power and show that this model leads to increased power when compared to traditional approaches. Moreover, we show that by using this model we are able to differentiate the genetic, environmental, and residual error contributions to the phenotype. Using predictions of these components, we show how the proportion of the phenotype due to environment and genetics can be predicted and show that the ranking of individuals based on these predictions is very accurate. The software implementing this method may be found at http://genetics.cs.ucla.edu/longGWAS/.

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Citations

Jul 18, 2014·PLoS Genetics·Jakris Eu-AhsunthornwattanaHeather J Cordell
Dec 19, 2014·BMC Proceedings·Phillip E Melton, Laura A Almasy
Feb 13, 2016·BMC Genetics·Yen-Feng ChiuPhillip E Melton
Jan 20, 2016·Genetic Epidemiology·Li-Chu ChienYen-Feng Chiu
May 3, 2016·Stat : the ISI's Journal for Rapid Dissemination of Statistics Research·Yubin SungSanjeena Subedi
Aug 13, 2014·Genetic Epidemiology·Zheyang WuPhillip E Melton
Apr 10, 2015·Biometrics·Zihuai HeBhramar Mukherjee
Nov 5, 2014·Frontiers in Genetics·Weiqiang WangZuoheng Wang
Dec 5, 2014·PLoS Computational Biology·Avital BrodtIrit Gat-Viks
Jan 6, 2017·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Nicolo Fusi, Jennifer Listgarten
May 26, 2017·Statistics in Medicine·Jing QianAndrea S Foulkes
Mar 31, 2018·Genetic Epidemiology·Pratyaydipta RudraDebashis Ghosh
Oct 12, 2014·G3 : Genes - Genomes - Genetics·Zitong LiM Rosario García-Gil
Dec 17, 2016·BMC Proceedings·Phillip E MeltonLaura Almasy
Nov 20, 2016·Genetic Epidemiology·Zhong WangZuoheng Wang

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