Genome-wide association of serum bilirubin levels in Korean population.

Human Molecular Genetics
Tae-Wook KangYong Sung Kim

Abstract

A large-scale, genome-wide association study was performed to identify genetic variations influencing serum bilirubin levels using 8841 Korean individuals. Significant associations were observed at UGT1A1 (rs11891311, P = 4.78 x 10(-148)) and SLCO1B3 (rs2417940, P = 1.03 x 10(-17)), which are two previously identified loci. The two single-nucleotide polymorphisms (SNPs) were replicated (rs11891311, P = 3.18 x 10(-15)) or marginally significant (rs2417940, P = 8.56 x 10(-4)) in an independent cohort of 1096 individuals. In a conditional analysis adjusted for the top UGT1A1 variant (rs11891311), another variant in UGT1A1 (rs4148323, P = 1.22 x 10(-121)) remained significant; this suggests that in UGT1A1 at least two independent genetic variations influence the bilirubin levels in the Korean population. The protein coding variant rs4148323, which is monomorphic in European-derived populations, may be specifically associated with serum bilirubin levels in Asians (P = 2.56 x 10(-70)). The SLCO1B3 variant (rs2417940, P = 1.67 x 10(-18)) remained significant in a conditional analysis for the top UGT1A1 variant. Interestingly, there were significant differences in the associated variations of SLCO1B3 between Koreans and European-derive...Continue Reading

References

Nov 2, 1995·The New England Journal of Medicine·P J BosmaR P Oude Elferink
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hideto JinnoJun-Ichi Sawada
Mar 6, 2003·American Journal of Human Genetics·Jing-Ping LinChristopher J O'Donnell
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Nov 3, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ichiro IeiriYuichi Sugiyama
May 3, 2005·Pharmacogenetics and Genomics·Ching-Shan HuangKung-Sheng Tang
Aug 5, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria Alexandra BritoDora Brites
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Wei ZhangHong-Hao Zhou
Feb 8, 2008·Genome Research·Dongliang GeDavid B Goldstein
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Hagenbuch, C Gui
Nov 1, 2008·Bioinformatics·Andrew D JohnsonPaul I W de Bakker
May 6, 2009·Human Molecular Genetics·Andrew D JohnsonJacqueline C Witteman
Sep 8, 2009·BMC Evolutionary Biology·Feng ChengChangqing Zeng

❮ Previous
Next ❯

Citations

Nov 22, 2011·Journal of Computer-aided Molecular Design·Samuel Genheden
Nov 17, 2011·European Journal of Human Genetics : EJHG·Guanjie ChenCharles N Rotimi
May 15, 2012·Pediatric Research·Laura Alencastro de AzevedoUrsula Matte
Oct 5, 2013·Italian Journal of Pediatrics·Jiebo LiuYuyuan Luo
Sep 27, 2015·Environmental Toxicology and Pharmacology·Suhg NamgoongHyoung Doo Shin
Sep 30, 2015·Clinical Pharmacology and Therapeutics·R S GammalUNKNOWN Clinical Pharmacogenetics Implementation Consortium
Jul 15, 2015·Human Molecular Genetics·Gabi KastenmüllerKarsten Suhre
May 15, 2015·Journal of Human Genetics·Nadimuthu VinayagamoorthyYeun-Jun Chung
Oct 29, 2014·The Pharmacogenomics Journal·J CusatoA D'Avolio
Sep 29, 2015·PloS One·Bahram NamjouJohn B Harley
Oct 24, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ryoichi FujiwaraMatthias Schwab
Jul 18, 2017·Nature Biotechnology·Nathan D PriceLeroy Hood
Apr 9, 2017·Stroke; a Journal of Cerebral Circulation·Sun Ju LeeSun Ha Jee
Mar 17, 2018·Scientific Reports·Shefali Setia VermaSarah A Pendergrass
Feb 23, 2020·PloS One·Ji Yeon SeoJeong Yoon Yim
Jan 28, 2014·Genetic Epidemiology·Bashira A CharlesCharles N Rotimi
Aug 9, 2020·Science Advances·Sungwon JeonJong Bhak
Feb 3, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Huiru ChangSusan E McCann
Jan 31, 2021·European Journal of Clinical Pharmacology·Tingyu WangGuosheng Cao
Sep 17, 2020·Science Advances·Sungwon JeonJong Bhak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.