Genome-wide association reveals the locus responsible for four-horned ruminant

Animal Genetics
James W KijasNoelle Cockett

Abstract

Phenotypic variability in horn characteristics, such as their size, number and shape, offers the opportunity to elucidate the molecular basis of horn development. The objective of this study was to map the genetic determinant controlling the production of four horns in two breeds, Jacob sheep and Navajo-Churro, and examine whether an eyelid abnormality occurring in the same populations is related. Genome-wide association mapping was performed using 125 animals from the two breeds that contain two- and four-horned individuals. A case-control design analysis of 570 712 SNPs genotyped with the ovine HD SNP Beadchip revealed a strong association signal on sheep chromosome 2. The 10 most strongly associated SNPs were all located in a region spanning Mb positions 131.9-132.6, indicating the genetic architecture underpinning the production of four horns is likely to involve a single gene. The closest genes to the most strongly associated marker (OAR2_132568092) were MTX2 and the HOXD cluster, located approximately 93 Kb and 251 Kb upstream respectively. The occurrence of an eyelid malformation across both breeds was restricted to polled animals and those carrying more than two horns. This suggests the eyelid abnormality may be associa...Continue Reading

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References

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Jun 24, 2015·Animal Genetics·Natalie Wiedemar, Cord Drögemüller

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Citations

Jan 11, 2018·Journal of the American Veterinary Medical Association·Zoe ReedPaul M Barrett
Jan 30, 2020·Scientific Reports·Mario BarbatoPaolo Ajmone-Marsan
Sep 30, 2020·Animals : an Open Access Journal From MDPI·Liliana Di StasioGiustino Gaspa
Feb 3, 2021·Molecular Biology and Evolution·Aurélie Allais-BonnetAurélien Capitan

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