Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.

Nature Genetics
Nobuhisa MizukiHidetoshi Inoko

Abstract

Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 x 10(-8)) and 1q32.1 (IL10, rs1554286, P = 8.0 x 10(-8)). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45).

References

Sep 1, 1982·Archives of Ophthalmology·S OhnoM Aizawa
Feb 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D M TurnerI V Hutchinson
Mar 26, 1998·Seminars in Arthritis and Rheumatism·V G KaklamaniP G Kaklamanis
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
May 4, 2006·The Journal of Clinical Investigation·Yoichiro Iwakura, Harumichi Ishigame
Feb 27, 2007·Human Immunology·Graham R WallaceMiles R Stanford
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Minoru IsomuraMasahiro Hiraoka
May 22, 2009·The New England Journal of Medicine·Gideon M HirschfieldKatherine A Siminovitch
Aug 18, 2009·Annals of the Rheumatic Diseases·Akira MeguroNobuhisa Mizuki

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Citations

Apr 30, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Joana M XavierSofia A Oliveira
May 12, 2012·Rheumatology International·Esin Aktas CetinGunnur Deniz
Jun 16, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·U PleyerN Stübiger
Nov 28, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·U PleyerN Stübiger
May 23, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T LappT Reinhard
Nov 10, 2012·Zeitschrift für Rheumatologie·I Kötter
Oct 12, 2012·Zeitschrift für Rheumatologie·I KötterC Deuter
Nov 2, 2011·Modern Rheumatology·Yeong Wook Song, Eun Ha Kang
Nov 20, 2012·Frontiers of Medicine·Shengping HouPeizeng Yang
Jun 8, 2012·Clinical Reviews in Allergy & Immunology·H YaziciE Seyahi
Oct 19, 2013·Experimental & Molecular Medicine·Sang Jin KimHyeong Gon Yu
Jun 12, 2013·Nature Genetics·UNKNOWN International Genetics of Ankylosing Spondylitis Consortium (IGAS)Matthew A Brown
Jul 6, 2011·Nature Reviews. Rheumatology·Ivona Aksentijevich, Daniel L Kastner
Sep 26, 2012·Nature Reviews. Rheumatology·Nicola L Ambrose, Dorian O Haskard
May 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yohei KirinoElaine F Remmers
Apr 23, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Houda BelguendouzChafia Touil-Boukoffa
Dec 24, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Koen Vandenbroeck
Mar 2, 2013·Zebrafish·Stefan H OehlersPhilip S Crosier
Oct 11, 2012·Bioinformatics·Daniela BörnigenYves Moreau
Jun 20, 2012·Rheumatology·Asmaa RadouaneMouna Barat-Houari
Jul 12, 2013·Rheumatology·F David CarmonaJavier Martín
Nov 22, 2013·Current Opinion in Rheumatology·Ahmet Gül
Jul 23, 2013·Current Opinion in Rheumatology·Seza Ozen, Fehime K Eroglu
Oct 9, 2012·Annals of the Rheumatic Diseases·Yun Jong LeeEun Bong Lee
Oct 21, 2011·Pathology Research International·Tamer İrfan Kaya
Apr 14, 2012·Orphanet Journal of Rare Diseases·David Saadoun, Bertrand Wechsler
Mar 25, 2011·Arthritis Research & Therapy·Eun Ha KangYeong Wook Song
May 2, 2012·Arthritis Research & Therapy·Sunao SugitaManabu Mochizuki
Nov 30, 2013·Arthritis Research & Therapy·Marco Antonio Montes-CanoMaría Francisca González-Escribano
Dec 12, 2012·Genome Medicine·René L WarrenRobert A Holt

❮ Previous
Next ❯

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