Genome-wide association studies in Crohn's disease: Past, present and future

Clinical & Translational Immunology
Bram VerstocktJames C Lee

Abstract

Over the course of the past decade, genome-wide association studies (GWAS) have revolutionised our understanding of complex disease genetics. One of the diseases that has benefitted most from this technology has been Crohn's disease (CD), with the identification of autophagy, the IL-17/IL-23 axis and innate lymphoid cells as key players in CD pathogenesis. Our increasing understanding of the genetic architecture of CD has also highlighted how a failure to suppress aberrant immune responses may contribute to disease development - a realisation that is now being incorporated into the design of new treatments. However, despite these successes, a significant proportion of disease heritability remains unexplained. Similarly, most of the causal variants at associated loci have not yet been identified, and even fewer have been functionally characterised. Because of the inarguable rise in the incidence of CD in regions of the world that previously had low disease rates, GWAS studies will soon have to shift from a largely Caucasian focus to include populations from other ethnic backgrounds. Future studies should also move beyond conventional studies of disease susceptibility into phenotypically driven 'within-cases' analyses in order to...Continue Reading

References

Sep 1, 1995·Clinical Immunology and Immunopathology·D RennickD Berg
Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
May 1, 1996·Gut·J SatsangiD P Jewell
Nov 17, 1998·The Journal of Experimental Medicine·M BoirivantW Strober
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Aug 24, 2001·The Journal of Clinical Investigation·G MonteleoneT T MacDonald
Nov 13, 2004·The New England Journal of Medicine·Peter J MannonUNKNOWN Anti-IL-12 Crohn's Disease Study Group
Feb 5, 2005·Science·Koichi S KobayashiRichard A Flavell
Oct 18, 2005·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Oct 18, 2005·International Journal of Colorectal Disease·Stefan FarkasEdward K Geissler
May 4, 2006·The Journal of Clinical Investigation·David YenDonna Rennick
Jul 29, 2006·Autophagy·Kristina B KruseArdythe A McCracken
Aug 12, 2006·The Journal of Biological Chemistry·Tomohiro YorimitsuDaniel J Klionsky
Oct 13, 2006·The Journal of Experimental Medicine·Sophie HueKevin J Maloy
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Mar 11, 2009·The Journal of Experimental Medicine·Melanie A KleinschekRobert A Kastelein
Jun 2, 2009·Nature Genetics·Ann K DalyUNKNOWN International SAE Consortium
Oct 28, 2009·Nature Reviews. Genetics·Robert PlominOliver S P Davis
Nov 6, 2009·The New England Journal of Medicine·Erik-Oliver GlockerChristoph Klein
Nov 17, 2009·Nature Genetics·UNKNOWN UK IBD Genetics ConsortiumDavid P Strachan
Feb 18, 2010·American Journal of Human Genetics·Eveliina JakkulaLeena Peltonen
Oct 19, 2010·Nature Genetics·UNKNOWN Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2Richard C Trembath

❮ Previous
Next ❯

Citations

Jan 30, 2019·Current Opinion in Organ Transplantation·Leonid BelyayevAlexander Kroemer
Apr 27, 2019·Annual Review of Immunology·Eric M BrownRamnik J Xavier
Oct 31, 2019·Clinical and Translational Gastroenterology·Inés Moret-TatayBelén Beltrán
Sep 4, 2019·PLoS Computational Biology·Sergio Picart-ArmadaBenoit H Dessailly
Nov 9, 2018·Current Opinion in Rheumatology·Eric GraceyDirk Elewaut
Feb 13, 2020·F1000Research·Simon P Borg-BartoloRahul Kalla
Jul 1, 2020·Tissue Engineering and Regenerative Medicine·Harikrishna Reddy RallabandiBo Ram Lee
Nov 7, 2018·World Journal of Stem Cells·Milton Artur RuizLuiz Gustavo De Quadros
Jun 22, 2018·Clinical & Translational Immunology·Manuel Ar Ferreira
Jan 9, 2019·Frontiers in Immunology·Bram VerstocktChristine Breynaert
Jan 17, 2021·Nutrients·Charlotte M VerburgtJohan E Van Limbergen
Nov 13, 2020·World Journal of Stem Cells·Milton Artur RuizRichard K Burt
Nov 9, 2019·Clinical and Translational Gastroenterology·Inés Moret-TatayBelén Beltrán
Apr 29, 2019·Journal of Molecular Biology·Christopher R ShalerBrian K Coombes
May 30, 2021·Bone Research·Nikolai JaschkeMartina Rauner
Aug 3, 2021·Experimental and Therapeutic Medicine·Shuangshuang LuJin Huang
May 8, 2021·Journal of Crohn's & Colitis·Katja A SelinEduardo J Villablanca

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
protein folding
antisense oligonucleotide
chips
chip

Clinical Trials Mentioned

NCT02675153

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms