Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Scientific Reports
Wanqing WenXiao-Ou Shu

Abstract

Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

References

Apr 21, 2001·Biometrics·B Devlin, K Roeder
Aug 8, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P DeurenbergS Guricci
Sep 18, 2007·Human Molecular Genetics·Precious J McLaughlinLihua Y Marmorstein
Sep 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Jonathan C K Wells
Dec 17, 2008·Nature Genetics·Cristen J WillerUNKNOWN Genetic Investigation of ANthropometric Traits Consortium
Mar 12, 2010·Nature·Joseph K PickrellJonathan K Pritchard
Jan 29, 2011·The American Journal of Clinical Nutrition·Inkyung BaikChol Shin
Mar 10, 2011·Diabetes·Aldi T KrajaIngrid B Borecki
Jul 16, 2011·Human Molecular Genetics·Lavinia PaternosterDebbie A Lawlor
Oct 6, 2011·European Journal of Human Genetics : EJHG·Fumihiko TakeuchiNorihiro Kato
Sep 8, 2012·Genome Research·Alan P BoyleMichael Snyder
Feb 3, 2015·American Journal of Human Genetics·Hugues AschardPeter Kraft
Feb 13, 2015·Nature·Dmitry ShunginKaren L Mohlke
Feb 13, 2015·Nature·Adam E LockeElizabeth K Speliotes

❮ Previous
Next ❯

Citations

Jan 20, 2018·Genetics·Fernando RacimoJoseph K Pickrell
Jan 25, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Xiao ZhangMelanie Ehrlich
Mar 15, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Sara DielsWim Van Hul
Dec 21, 2018·Journal of Bioinformatics and Computational Biology·Sungkyoung ChoiTaesung Park
Aug 30, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T WangW Jia
May 20, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Michelle TurcotteDavid Meyre
Feb 17, 2018·International Journal of Epidemiology·Kristin Hui Xian TanRob M van Dam
Mar 13, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S-S DongT-L Yang
Sep 12, 2020·Biomolecules·Imogen LivingstoneAkira Wiberg
Feb 6, 2017·Genomics & Informatics·Sungkyoung ChoiTaesung Park
Jun 13, 2017·The Journal of Clinical Endocrinology and Metabolism·Maria PetterssonAnna Lindstrand
Jan 25, 2019·PLoS Genetics·Fernando Riveros-McKayI Sadaf Farooqi
Nov 28, 2018·Nature Genetics·Rachel MooreOliver Stegle
Nov 20, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yeongseon AhnYoon Shin Cho
Apr 5, 2021·Diabetes & Metabolic Syndrome·Gagandeep Kaur WaliaVipin Gupta

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
ChIP-Seq

Software Mentioned

GIANT
ChromHMM
METAL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
L-Y ChienJ-J Chen
Circulation Journal : Official Journal of the Japanese Circulation Society
Yasuyuki NakamuraHirotsugu Ueshima
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Song-ming DuYong-hua Hu
© 2022 Meta ULC. All rights reserved