Nov 1, 2018

Genome-Wide Association Studies of malaria susceptibility and resistance: progress, pitfalls and prospects

BioRxiv : the Preprint Server for Biology
Delesa DamenaEmile Chimusa

Abstract

P. falciparum malaria is still among the leading causes of child mortality in sub-Saharan Africa; killing hundreds of thousands of children each year. Malaria has been recognized as one of the prominent evolutionary selective forces of human genome that led to the emergence of multiple host protective polymorphisms associated with minimizing the risk of developing severe malaria in endemic areas. A comprehensive understanding of the genetic bases of malaria resistance can shed light to the molecular mechanisms of host-parasite interactions that can potentially pave ways to the development of new therapeutics and vaccines. Genome-wide association studies (GWASs) have recently been implemented in malaria endemic areas and identified a number of novel association genetic variants. Despite this success, only few variants did replicate across the studies and the underlying biology is yet to be understood for the majority of the novel variants. Besides, there are several open questions around heritability, polygenic effects, epistatic interactions, genetic correlations and associated molecular pathways among others. In this review, we first assess the progress and pitfalls of malaria susceptibility GWASs. We then, provide an overview...Continue Reading

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Mentioned in this Paper

Gene Polymorphism
Genome-Wide Association Study
Study
Biochemical Pathway
Genome
Vaccines
Malaria
Multicenter Study
Malaria Vaccines
Disease Susceptibility

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