Genome-wide association study and in silico functional analysis of the number of embryos produced by Holstein donors

Journal of Dairy Science
C JatonF Miglior

Abstract

Superovulation or ovum pick-up and in vitro fertilization are technologies used to produce an increased number of embryos from elite females. Embryo production traits have been shown to be heritable, but the genes that cause this variability have not yet been assessed. The main objectives of this study were to perform a genome-wide association study (GWAS) to find single nucleotide polymorphisms (SNP) associated with embryo production traits and to identify candidate genes affecting the number of embryos produced by Holstein donors in Canada that may provide insight into the regulation of embryo production. Breeding values were estimated and de-regressed for all donors and sires using a data set of 150,971 records of superovulation or ovum pick-up and in vitro fertilization. A total of 11,607 animals were genotyped, but of that number only 5,118 were genotyped with at least a 50K SNP panel and had a de-regressed estimated breeding value reliability of at least 10%. For the GWAS, 606,406 imputed SNP on 29 autosomal chromosomes were considered after applying quality control measures. A single-SNP univariate mixed linear animal model was used to perform the GWAS, and a 5% false discovery rate was applied to adjust for multiple tes...Continue Reading

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Citations

Feb 7, 2020·Animal : an International Journal of Animal Bioscience·U BesenfelderV Havlicek
Jan 1, 2019·Reproduction, Fertility, and Development·C JatonF Miglior
Jan 1, 2019·Reproduction, Fertility, and Development·M MikkolaJ Taponen

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