Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Ryan L MinsterAnne B Newman

Abstract

The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted for mortality risk in 3,140 individuals selected for familial longevity from the Long Life Family Study. The genome-wide association study used the Long Life Family Study as the discovery cohort and individuals from the Cardiovascular Health Study and the Framingham Heart Study as replication cohorts. There were no genome-wide significant findings from the genome-wide association study; however, several single-nucleotide polymorphisms near ZNF704 on chromosome 8q21.13 were suggestively associated with the HAI in the Long Life Family Study (p < 10(-) (6)) and nominally replicated in the Cardiovascular Health Study and Framingham Heart Study. Linkage results revealed significant evidence (log-odds score = 3.36) for a quantitative trait locus for mortality-optimized HAI in women on chromosome 9p24-p23. However, results of fine-mapping studies did not implicate any specific candidate genes within this region of interest. ZNF704 may be a potential candidate gene ...Continue Reading

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Citations

Apr 30, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dobril K IvanovJanet M Thornton
Sep 4, 2015·Age·N G BediagaM M de Pancorbo
Aug 17, 2016·Cancers·Aditi J Ravindranath, Ken M Cadigan
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May 8, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Matthew D L O'ConnellAnne B Newman
Aug 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lauren N ShaverKristen M Beavers
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jatinder SinghCandace M Kammerer
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May 14, 2021·Journal of the American Chemical Society·Bo DuanBin Xia

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