Genome-Wide Association Study for Susceptibility to and Recoverability From Mastitis in Danish Holstein Cows

Frontiers in Genetics
B G WelderufaelW F Fikse

Abstract

Because mastitis is very frequent and unavoidable, adding recovery information into the analysis for genetic evaluation of mastitis is of great interest from economical and animal welfare point of view. Here we have performed genome-wide association studies (GWAS) to identify associated single nucleotide polymorphisms (SNPs) and investigate the genetic background not only for susceptibility to - but also for recoverability from mastitis. Somatic cell count records from 993 Danish Holstein cows genotyped for a total of 39378 autosomal SNP markers were used for the association analysis. Single SNP regression analysis was performed using the statistical software package DMU. Substitution effect of each SNP was tested with a t-test and a genome-wide significance level of P-value < 10-4 was used to declare significant SNP-trait association. A number of significant SNP variants were identified for both traits. Many of the SNP variants associated either with susceptibility to - or recoverability from mastitis were located in or very near to genes that have been reported for their role in the immune system. Genes involved in lymphocyte developments (e.g., MAST3 and STAB2) and genes involved in macrophage recruitment and regulation of i...Continue Reading

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Citations

Dec 22, 2020·PLoS Computational Biology·Christopher M PooleyAndrea B Doeschl-Wilson
Feb 5, 2021·Animals : an Open Access Journal From MDPI·Riccardo MorettiPaola Sacchi
Feb 9, 2021·Frontiers in Genetics·Antonia NoceAndreas Hoeflich
May 15, 2021·Journal of Animal Science and Technology·Ayele MandefroHailu Dadi

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Methods Mentioned

BETA
genotyping
MDS
glycosylation

Software Mentioned

GeneCards
DMU
PLINK
MCMCglmm
Ensembl
R

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