Genome-wide association study (GWAS) for growth rate and age at sexual maturation in Atlantic salmon (Salmo salar)

PloS One
Alejandro P GutierrezW S Davidson

Abstract

Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors, selection for these traits has been continuously accomplished since the beginning of Atlantic salmon selective breeding programs. In this genome-wide association study (GWAS) we used a 6.5K single-nucleotide polymorphism (SNP) array to genotype ∼ 480 individuals from the Cermaq Canada broodstock program and search for SNPs associated with growth and age at sexual maturation. Using a mixed model approach we identified markers showing a significant association with growth, grilsing (early sexual maturation) and late sexual maturation. The most significant associations were found for grilsing, with markers located in Ssa10, Ssa02, Ssa13, Ssa25 and Ssa12, and for late maturation with markers located in Ssa28, Ssa01 and Ssa21. A lower level of association was detected with growth on Ssa13. Candidate genes, which were linked to these genetic markers, were identified and some of them show a direct relationship with developmental processes,...Continue Reading

References

Jun 1, 1971·Biochemical Genetics·L M Karig, A C Wilson
Nov 27, 1998·Neuroscience Research·Y HataY Takai
Jan 15, 2000·Molecular Cell·B Stebbins-BoazJ D Richter
Jun 19, 2004·Genomics·Theologia SarafidouUNKNOWN European Collaborative Consortium for the Study of ADLTE
Sep 15, 2004·Trends in Biochemical Sciences·Adrian P BrackenKristian Helin
Aug 6, 2005·Current Opinion in Genetics & Development·Michael Korenjak, Alexander Brehm
Sep 5, 2006·Genetics·Ruth B PhillipsGary H Thorgaard
Dec 13, 2006·Genome Biology·Aurora Ruiz-HerreraTerence J Robinson
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Apr 17, 2007·Genetics, Selection, Evolution : GSE·Anna K Sonesson
Apr 18, 2007·Biological Reviews of the Cambridge Philosophical Society·C Garcia de LeanizT P Quinn
Jun 15, 2007·Human Molecular Genetics·Kim Debacker, R Frank Kooy
May 19, 2009·Nature Reviews. Genetics·Michael E Goddard, Ben J Hayes
Jul 9, 2009·Nature Reviews. Genetics·Trudy F C MackayJulien F Ayroles
May 11, 2010·Journal of Applied Genetics·Y-Z HuangJ-Q Wang
Jun 8, 2010·Genetics, Selection, Evolution : GSE·Matthew BaranskiDag Inge Våge
Oct 5, 2010·Genome Biology·William S DavidsonStig W Omholt
Apr 19, 2016·Nature·Sigbjørn LienWilliam S Davidson

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Citations

Dec 26, 2015·International Journal of Molecular Sciences·Hsin Y TsaiRoss D Houston
Jul 1, 2016·Genetics, Selection, Evolution : GSE·Hsin-Yuan TsaiRoss D Houston
Apr 6, 2018·PloS One·Kris A ChristensenRobert H Devlin
Aug 8, 2018·Animal : an International Journal of Animal Bioscience·F H RodríguezJ M Yáñez
May 17, 2017·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M A ToroB Villanueva
Aug 4, 2018·Frontiers in Genetics·Christopher M Hollenbeck, Ian A Johnston
Feb 1, 2020·BMC Research Notes·Aya Sato, Masakado Kawata
Aug 26, 2016·G3 : Genes - Genomes - Genetics·Xin GengZhanjiang Liu
Oct 26, 2018·Frontiers in Genetics·Lin ChenPeng Xu
Feb 9, 2020·The Journal of Experimental Biology·Asano Ishikawa, Jun Kitano
Dec 13, 2017·Molecular Genetics and Genomics : MGG·Ning LiZhanjiang Liu

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Datasets Mentioned

BETA
AGKD01068032
AGKD01242239

Methods Mentioned

BETA
genotyping
chip

Software Mentioned

BLAST
BLASTn
BLASTx
GRAMMAR
R
GenABEL

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