Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.

PloS One
Liang XieXiquan Zhang

Abstract

Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still a challenge. In this genome-wide association study (GWAS), we identified a narrow 1.5 Mb region (173.5-175 Mb) of chicken (Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0-90 d of age measured weekly, biweekly average daily gains (ADG) derived from weekly body weight, and breast muscle weight (BMW), leg muscle weight (LMW) and wing weight (WW) at 90 d of age. Five SNPs in the 1.5 Mb KPNA3-FOXO1A region at GGA1 had the highest significant effects for all growth traits in this study, including a SNP at 8.9 Kb upstream of FOXO1A for BW at 22-48 d and 70 d, a SNP at 1.9 Kb downstream of FOXO1A for WW, a SNP at 20.9 Kb downstream of ENSGALG00000022732 for ADG at 29-42 d, a SNP in INTS6 for BW at 90 d, and a SNP in KPNA3 for BMW and LMW. The 1.5 Mb KPNA3-FOXO1A region contained two microRNA genes that could bind...Continue Reading

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Citations

Sep 11, 2012·Journal of Animal Science and Biotechnology·Hui ZhangHui Li
Jul 21, 2015·International Journal of Molecular Sciences·Hongjia OuyangXiquan Zhang
Nov 17, 2015·Genome Biology and Evolution·S QanbariH Simianer
Oct 27, 2015·Animal Reproduction Science·G X ZhangH Q Shi
Oct 12, 2012·Annals of the New York Academy of Sciences·James E WomackMi Ok Lee
Nov 19, 2015·Genetics, Selection, Evolution : GSE·Yuna HeLusheng Huang
Dec 18, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chenglong LuoDingming Shu
Oct 17, 2016·Journal of Molecular Cell Biology·Ming-Shan WangYa-Ping Zhang
Feb 10, 2017·Scientific Reports·Fábio PértilleLuiz Lehmann Coutinho
Sep 30, 2017·Molecular Biology and Evolution·Ming-Shan WangYa-Ping Zhang
Jul 20, 2016·PloS One·Manman ShenNing Yang
Apr 23, 2014·G3 : Genes - Genomes - Genetics·Yanfa SunJie Wen
Apr 30, 2019·PLoS Genetics·Saber QanbariLeif Andersson
Jun 27, 2019·Scientific Reports·Eirini TarsaniAntonios Kominakis
Jan 27, 2019·Genetics, Selection, Evolution : GSE·Sanne van den BergRoel F Veerkamp
Mar 18, 2020·Animals : an Open Access Journal From MDPI·Rong FuXiquan Zhang
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Mohammadreza MohammadabadiWei Guo

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Methods Mentioned

BETA
genotyping
chip
Assay

Software Mentioned

TargetScan
Ensembl
RNA22
epiSNP
Sequenom
Typer
Haploview
RNAhybrid
SNPEVG
Minitab

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