Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction.

Nature Genetics
Connie R BezzinaArthur A M Wilde

Abstract

Sudden cardiac death from ventricular fibrillation during acute myocardial infarction is a leading cause of total and cardiovascular mortality. To our knowledge, we here report the first genome-wide association study for this trait, conducted in a set of 972 individuals with a first acute myocardial infarction, 515 of whom had ventricular fibrillation and 457 of whom did not, from the Arrhythmia Genetics in The Netherlands (AGNES) study. The most significant association to ventricular fibrillation was found at 21q21 (rs2824292, odds ratio = 1.78, 95% CI 1.47-2.13, P = 3.3 x 10(-10)). The association of rs2824292 with ventricular fibrillation was replicated in an independent case-control set consisting of 146 out-of-hospital cardiac arrest individuals with myocardial infarction complicated by ventricular fibrillation and 391 individuals who survived a myocardial infarction (controls) (odds ratio = 1.49, 95% CI 1.14-1.95, P = 0.004). The closest gene to this SNP is CXADR, which encodes a viral receptor previously implicated in myocarditis and dilated cardiomyopathy and which has recently been identified as a modulator of cardiac conduction. This locus has not previously been implicated in arrhythmia susceptibility.

Associated Clinical Trials

Jan 2, 2017·Connie Bezzina

References

Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·R P TomkoL Philipson
Jan 28, 1998·Circulation·Y FriedlanderL A Cobb
Nov 24, 1998·Circulation·D P Zipes, H J Wellens
Apr 20, 1999·Circulation·X JouvenP Ducimetière
Apr 9, 2001·Journal of Cardiovascular Electrophysiology·R J Myerburg
Jan 17, 2002·The New England Journal of Medicine·H V HuikuriR J Myerburg
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Jun 20, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Roseline GodboutDwayne A Bisgrove
Apr 3, 2004·Circulation Research·Dan E ArkingPeter M Spooner
Nov 19, 2004·American Journal of Human Genetics·Dirk A Kleinjan, Veronica van Heyningen
Sep 16, 2005·Heart·Arthur A M Wilde, Connie R Bezzina
Oct 7, 2005·Journal of Hypertension·Charles AgyemangUNKNOWN SUNSET (Surinamese in The Netherlands: Study on Ethnicity and Health) Study Group
Jan 31, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Robert J Myerburg, Agustin Castellanos
May 2, 2006·Nature Genetics·Dan E ArkingAravinda Chakravarti
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Jan 18, 2008·Genetic Epidemiology·Clive J HoggartDavid J Balding
Jul 26, 2008·Heart·H WatkinsW J McKenna
Sep 17, 2008·The Journal of Experimental Medicine·Ulrike LisewskiMichael Gotthardt
Oct 29, 2008·Circulation·Peter A Noseworthy, Christopher Newton-Cheh
Nov 1, 2008·Bioinformatics·Andrew D JohnsonPaul I W de Bakker
Mar 24, 2009·Nature Genetics·Christopher Newton-ChehBruno H Ch Stricker
Mar 24, 2009·Nature Genetics·Arne PfeuferAravinda Chakravarti
Aug 1, 2009·Human Molecular Genetics·Mark EijgelsheimBruno H C Stricker
Oct 1, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M L SampietroJ W Jukema

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Citations

Mar 25, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marit DietelIngo B Runnebaum
Mar 9, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Eric C Stecker, Sumeet S Chugh
Apr 9, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Dan M Roden
Apr 5, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·R F J MarsmanC R Bezzina
Dec 2, 2011·The New England Journal of Medicine·Christopher J O'Donnell, Elizabeth G Nabel
Jan 18, 2011·European Heart Journal·Frank I Marcus, Sumeet S Chugh
Nov 1, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Akinori SatoYoshifusa Aizawa
Jul 25, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jonas S S G de Jong, Hanno L Tan
Mar 25, 2011·Current Opinion in Cardiology·Nagesh Chopra, Björn C Knollmann
Aug 24, 2012·Journal of Hypertension·Priya B ShettyUNKNOWN Candidate Gene Association Resource (CARe) Consortium
Feb 2, 2012·Circulation·Rajat Deo, Christine M Albert
Jun 19, 2012·The Journal of Clinical Investigation·Malou van den BoogaardVincent M Christoffels
Aug 24, 2012·PloS One·Abdennasser BardaiHanno L Tan
Dec 11, 2013·Nature Reviews. Cardiology·Roos F MarsmanConnie R Bezzina
Aug 24, 2013·Briefings in Functional Genomics·Karel van DuijvenbodenVincent M Christoffels
Aug 21, 2013·Briefings in Functional Genomics·Elisabeth M Lodder, Connie R Bezzina
Jun 19, 2012·Annual Review of Genomics and Human Genetics·Dan E Arking, Nona Sotoodehnia
May 8, 2014·European Heart Journal·Hein J J WellensArthur A Wilde
Aug 31, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bulent GorenekIrene Savelieva
Oct 12, 2010·Current Cardiovascular Risk Reports·Raha PazokiConnie R Bezzina
Jul 3, 2013·Current Cardiology Reports·Elena DolmatovaSteven A Lubitz
Apr 12, 2014·Current Opinion in Pharmacology·Dan M Roden
Mar 26, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Adriana Huertas-VazquezSumeet S Chugh
Sep 11, 2012·Revista Española De Cardiología·Antonio Bayés de Luna, Roberto Elosua
Aug 30, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Bulent GorenekUwe Zeymer
Feb 18, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Lia CrottiCharles Antzelevitch
Dec 20, 2011·Forensic Science International : Synergy·M K LarsenJ Banner
Nov 15, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Darshan DalalArthur A M Wilde
Jun 28, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Carmen TeodorescuSumeet S Chugh
Apr 15, 2015·Journal of Molecular and Cellular Cardiology·J Gustav Smith, Christopher Newton-Cheh
Feb 8, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Connie R Bezzina
Jul 7, 2014·Journal of the American College of Cardiology·Wataru Shimizu
Jun 27, 2015·IJC Heart & Vasculature·Adriana Huertas-VazquezSumeet S Chugh
Mar 25, 2015·Revista Española De Cardiología·Belén Álvarez-ÁlvarezJosé Ramón González-Juanatey

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