DOI: 10.1101/498824Dec 20, 2018Paper

Genome-wide association study of alcohol consumption in Russian population

BioRxiv : the Preprint Server for Biology
Igor NizamutdinovAlexander Rakitko

Abstract

Liability to alcohol dependence is heritable, but little is known about its complex polygenic architecture. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 1798 of Russian individuals. No SNP reached genome-wide significance for any alcohol drinking patterns: never drinking, everyday drinking, once per week drinking and once per month drinking. Polymorphisms in previously reported genes of KLB and AUTS2 were significant associated with everyday drinking and once per week drinking patterns, respectively. We also found associations of genes involved in nervous system function and mental disorders with some alcohol drinking patterns. This study identifies novel gene associations that should be the focus of future studies investigating the neurobiology of alcohol consumption.

Related Concepts

Mental Disorders
Genes
Genome
Neurobiology
Russians
Gene Polymorphism
Single Nucleotide Polymorphism
Genome-Wide Association Study
Study
Self-Report

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