Genome-wide association study of conformation and milk yield in mixed-breed dairy goats

Journal of Dairy Science
Sebastian MuchaJoanne Conington

Abstract

Identification of genetic markers that affect economically important traits is of high value from a biological point of view, enabling the targeting of candidate genes and providing practical benefits for the industry such as wide-scale genomic selection. This study is one of the first to investigate the genetic background of economically important traits in dairy goats using the caprine 50K single nucleotide polymorphism (SNP) chip. The aim of the project was to perform a genome-wide association study for milk yield and conformation of udder, teat, and feet and legs. A total of 137,235 milk yield records on 4,563 goats each scored for 10 conformation traits were available. Out of these, 2,381 goats were genotyped with the Illumina Caprine 50K BeadChip (Illumina Inc., San Diego, CA). A range of pseudo-phenotypes were used including deregressed breeding values and pseudo-estimated breeding values. Genome-wide association studies were performed using the multi-locus mixed model (MLMM) algorithm implemented in SNP & Variation Suite v7.7.8 (Golden Helix Inc., Bozeman, MT). A genome-wise significant [-log10(P-value) > 5.95] SNP for milk yield was identified on chromosome 19, with additional chromosome-wise significant (-log10(P-valu...Continue Reading

References

Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·F A Ponce de LeonC W Beattie
Jul 10, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·W CoppietersM Georges
Jul 11, 2001·Small Ruminant Research : the Journal of the International Goat Association·E MalveiroA Cravador
Mar 22, 2005·Journal of Dairy Science·P SacchiA Caroli
May 16, 2008·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·D L RoldánR J C Cantet
Oct 24, 2008·Journal of Dairy Science·P M VanRaden
Jan 2, 2010·Genetics, Selection, Evolution : GSE·Dorian J GarrickRohan L Fernando
Jun 12, 2010·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·S BolormaaA Ruvinsky
Dec 25, 2010·Journal of Dairy Science·A SewalemG J Kistemaker
Aug 26, 2011·Genetics, Selection, Evolution : GSE·Binyam S DagnachewTormod Ådnøy
Dec 12, 2012·Animal Genetics·James W KijasUNKNOWN International Goat Genome Consortium
Apr 25, 2013·The Journal of Dairy Research·Maria Luisa DettoriGiuseppe Massimo Vacca
Dec 24, 2013·G3 : Genes - Genomes - Genetics·Chinyere C EkineDirk-Jan de Koning
Jan 28, 2014·PloS One·Gwenola Tosser-KloppUNKNOWN International Goat Genome Consortium
Mar 5, 2015·Animal Genetics·I ReberC Drögemüller
Sep 8, 2015·Journal of Dairy Science·S MuchaJ Conington
Dec 13, 2016·Journal of Dairy Science·V J Castañeda-BustosG Torres-Hernández

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Citations

Nov 14, 2019·BMC Genetics·Enrique Sánchez-MolanoGeorgios Banos
Mar 17, 2020·Journal of Animal Science and Biotechnology·Dailu GuanMarcel Amills
Jun 4, 2020·Journal of Animal Science and Biotechnology·Megan ScholtensHugh Blair
Jul 31, 2019·Asian-Australasian Journal of Animal Sciences·Terry A Gipson
Oct 19, 2020·Journal of Dairy Science·Maria Gracia Luigi-SierraMarcel Amills
Nov 3, 2020·Journal of Dairy Science·Estelle TalouarnChristèle Robert-Granié
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Ibrahim AbousolimanKlaus Wimmers
Aug 1, 2021·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Onur YilmazIbrahim Cemal
Sep 12, 2021·Genetics, Selection, Evolution : GSE·Ran LiYu Jiang

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