Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank

Diabetologia
Tove FallErik Ingelsson

Abstract

Coronary artery disease (CAD) is a common complication among individuals with diabetes. A better understanding of the genetic background of CAD in this population has the potential to suggest novel molecular targets for screening, risk assessment and drug development. We performed a genome-wide association study of CAD in 15,666 unrelated individuals (3,968 CAD cases and 11,698 controls) of white British ancestry with diabetes at inclusion in the UK Biobank study. Our results were compared with results from participants without diabetes. We found genome-wide significant evidence for association with CAD at the previously well-established LPA locus (lead variant: rs74617384; OR 1.38 [95% CI 1.26, 1.51], p = 3.2 × 10-12) and at 9p21 (lead variant: rs10811652; OR 1.19 [95% CI 1.13, 1.26], p = 6.0 × 10-11). Moreover, other variants previously associated with CAD showed similar effects in the participants with and without diabetes, indicating that the genetic architecture of CAD is largely the same. Our results indicate large similarities between the genetic architecture of CAD in participants with and without diabetes. Larger studies are needed to establish whether there are important diabetes-specific CAD loci.

References

Oct 16, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Alex S F DoneyColin N A Palmer
Jul 17, 2010·Bioinformatics·Randall J PruimCristen J Willer
Aug 29, 2013·JAMA : the Journal of the American Medical Association·Lu QiAlessandro Doria
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Apr 18, 2015·PLoS Computational Biology·Christiaan A de LeeuwDanielle Posthuma
May 23, 2017·Nature Genetics·Joanna M M HowsonDanish Saleheen
Dec 1, 2017·Nature Communications·Kyoko WatanabeDanielle Posthuma

❮ Previous
Next ❯

Citations

Dec 16, 2020·Circulation. Genomic and Precision Medicine·Natalie R van ZuydamUNKNOWN SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee*
May 13, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Songzan ChenWenbin Zhang
May 29, 2021·Nucleic Acids Research·Niccolo TesiMarcel J T Reinders
May 28, 2021·Frontiers in Cardiovascular Medicine·Dara VakiliDeepak L Bhatt

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

CARDIoGRAMplusC4D
MAGMA
PLINK
Locuszoom

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.