Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.

Nature Genetics
Lucia CondeChristine F Skibola

Abstract

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).

Associated Clinical Trials

References

Dec 3, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·O NathalangT Sriphaisal
Jun 19, 2004·Hematology·Y Al-TonbaryR El-Shawaf
Feb 3, 2005·Journal of the National Cancer Institute·Karin Ekström SmedbyHans-Olov Adami
Jul 4, 2007·Haematologica·Christine F SkibolaAlexandra Nieters
Feb 28, 2008·International Journal of Hematology·Hee-Baeg ChoiTai-Gyu Kim
Sep 2, 2008·Nature Genetics·Maria Chiara Di BernardoRichard S Houlston
Jul 22, 2009·Nature Genetics·Christine F SkibolaKevin M Brown

❮ Previous
Next ❯

Citations

Jun 17, 2011·Human Genetics·Charles C Chung, Stephen J Chanock
Aug 24, 2012·Genes and Immunity·H KitajimaK Yamamoto
Aug 21, 2013·Nature Genetics·Daniel ChubbHartmut Goldschmidt
Oct 23, 2013·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Itamar EskinEran Halperin
Apr 16, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christina A ClarkeEllen T Chang
Aug 23, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·James R CerhanSusan L Slager
Jan 22, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aaron E HoffmanYong Zhu
Oct 3, 2012·BMC Genomics·Christine F SkibolaKarin E Smedby
Dec 18, 2013·Seminars in Cancer Biology·Eva BaecklundRichard Rosenquist
Sep 1, 2014·Journal of the National Cancer Institute. Monographs·Lindsay M MortonSusan L Slager
Nov 2, 2014·Blood Cancer Journal·Y W AsmannA J Novak
Oct 3, 2012·Advances in Hematology·Alexander J AmbinderChristopher R Flowers
Dec 8, 2010·Leukemia & Lymphoma·Nicholas K AkersChristine F Skibola
Jun 6, 2015·Leukemia & Lymphoma·Kaspar Rene NielsenHans Erik Johnsen
Apr 9, 2014·Leukemia & Lymphoma·Amy E KennedyM Tevfik Dorak
Jul 4, 2012·Expert Opinion on Medical Diagnostics·Shuangge Ma
Nov 8, 2011·Expert Opinion on Medical Diagnostics·Yawei ZhangShuangge Ma
Oct 9, 2014·BMC Medical Genetics·Fredrik BaecklundKarin E Smedby
Nov 20, 2013·Seminars in Hematology·Susan L SlagerLynn R Goldin
Sep 29, 2011·Seminars in Cancer Biology·Karin E Smedby, Henrik Hjalgrim
Jun 11, 2011·Best Practice & Research. Clinical Haematology·James R Cerhan
Jun 26, 2013·British Journal of Haematology·Lucia CondeChristine F Skibola
Sep 16, 2011·International Journal of Cancer. Journal International Du Cancer·Daniele CampaAlexandra Nieters
Dec 16, 2011·Environmental and Molecular Mutagenesis·Bryan A BassigQing Lan
Sep 17, 2013·British Journal of Haematology·Megan H ShirleyRaghib Ali

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.