Genome-wide association study of insect bite hypersensitivity in Dutch Shetland pony mares

Animal Genetics
A SchurinkJ A M van Arendonk

Abstract

Insect bite hypersensitivity (IBH) is the most common allergic disease present in horses worldwide. It has been shown that IBH is under genetic control, but the knowledge of associated genes is limited. We conducted a genome-wide association study to identify and quantify genomic regions contributing to IBH in the Dutch Shetland pony population. A total of 97 cases and 91 controls were selected and matched on withers height, coat colour and pedigree to minimise the population stratification. A blood sample was collected from participating Shetland pony mares, their IBH phenotype was scored and the owner filled in a questionnaire. A total of 40 021 single-nucleotide polymorphisms (SNPs) were fitted in a univariable logistic model fitting an additive effect. Analysis revealed no effects of population stratification. Significant associations with IBH were detected for 24 SNPs on 12 chromosomes [-log(10) (P-value) > 2.5]. Odds ratios of allele substitution effects of the unfavourable allele were between 1.94 and 5.95. The most significant SNP was found on chromosome 27, with an odds ratio of 2.31 and with an allele frequency of the unfavourable allele of 0.72 in cases and 0.53 in controls. Genome-wide association studies on additio...Continue Reading

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Citations

Nov 1, 2012·Genetics, Selection, Evolution : GSE·Anouk SchurinkJohan A M van Arendonk
May 31, 2015·The Journal of Heredity·Merina ShresthaGabriella Lindgren
Sep 7, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Merina ShresthaGabriella Lindgren
Feb 9, 2017·Journal of Animal Science·J CitekV Prantlova

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