Genome-Wide Association Study of Metabolic Syndrome Reveals Primary Genetic Variants at CETP Locus in Indians

Biomolecules
Gauri PrasadINDICO

Abstract

Indians, a rapidly growing population, constitute vast genetic heterogeneity to that of Western population; however they have become a sedentary population in past decades due to rapid urbanization ensuing in the amplified prevalence of metabolic syndrome (MetS). We performed a genome-wide association study (GWAS) of MetS in 10,093 Indian individuals (6,617 MetS and 3,476 controls) of Indo-European origin, that belong to our previous biorepository of The Indian Diabetes Consortium (INDICO). The study was conducted in two stages-discovery phase (N = 2,158) and replication phase (N = 7,935). We discovered two variants within/near the CETP gene-rs1800775 and rs3816117-associated with MetS at genome-wide significance level during replication phase in Indians. Additional CETP loci rs7205804, rs1532624, rs3764261, rs247617, and rs173539 also cropped up as modest signals in Indians. Haplotype association analysis revealed GCCCAGC as the strongest haplotype within the CETP locus constituting all seven CETP signals. In combined analysis, we perceived a novel and functionally relevant sub-GWAS significant locus-rs16890462 in the vicinity of SFRP1 gene. Overlaying gene regulatory data from ENCODE database revealed that single nucleotide p...Continue Reading

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Citations

Jul 22, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Inês PreguiçaFlávio Reis
Sep 12, 2019·Communications Biology·Varun WarrierSimon Baron-Cohen
May 5, 2020·Molecular Genetics and Genomics : MGG·Anil K GiriDwaipayan Bharadwaj
Apr 16, 2021·Cardiovascular Drugs and Therapy·Haocheng LuMinerva T Garcia-Barrio

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Methods Mentioned

BETA
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Software Mentioned

PLINK
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ENCODE
R
GenomeStudio
JASPAR
UCSC browser
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