DOI: 10.1101/458299Nov 2, 2018Paper

Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures

BioRxiv : the Preprint Server for Biology
Shuai LiR L Milne

Abstract

Age- and body mass index (BMI)-adjusted mammographic density is one the strongest breast cancer risk factors. DNA methylation is a molecular mechanism that could underlie inter-individual variation in mammographic density. We aimed to investigate the association between breast cancer risk-predicting mammographic density measures and blood DNA methylation. For 436 women from the Australian Mammographic Density Twins and Sisters Study and 591 women from the Melbourne Collaborative Cohort Study, mammographic density (dense area, non-dense area and percentage dense area) defined by the conventional brightness threshold was measured using the CUMULUS software, and peripheral blood DNA methylation was measured using the HumanMethylation450 (HM450) BeadChip assay. Associations between DNA methylation at >400,000 sites and mammographic density measures adjusted for age and BMI were assessed within each cohort and pooled using fixed-effect meta-analysis. Associations with methylation at genetic loci known to be associated with mammographic density were also examined. We found no genome-wide significant (P<10-7) association for any mammographic density measure from the meta-analysis, or from the cohort-specific analyses. None of the 299 ...Continue Reading

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