Genome-Wide Association Study of Psychosis Proneness in the Finnish Population

Schizophrenia Bulletin
Alfredo Ortega-AlonsoWilliam Hennah

Abstract

The current study examined quantitative measures of psychosis proneness in a nonpsychotic population, in order to elucidate their underlying genetic architecture and to observe if there is any commonality to that already detected in the studies of individuals with overt psychotic conditions, such as schizophrenia and bipolar disorder. Heritability, univariate and multivariate genome-wide association (GWAs) tests, including a series of comprehensive gene-based association analyses, were developed in 4269 nonpsychotic persons participating in the Northern Finland Birth Cohort 1966 study with information on the following psychometric measures: Hypomanic Personality, Perceptual Aberration, Physical and Social Anhedonia (also known as Chapman's Schizotypia scales), and Schizoidia scale. Genome-wide genetic data was available for ~9.84 million SNPs. Heritability estimates ranged from 16% to 27%. Phenotypic, genetic and environmental correlations ranged from 0.04-0.43, 0.25-0.73, and 0.12-0.43, respectively. Univariate GWAs tests revealed an intronic SNP (rs12449097) at the TMC7 gene (16p12.3) that significantly associated (P = 3.485 × 10-8) with the hypomanic scale. Bivariate GWAs tests including the hypomanic and physical anhedonia ...Continue Reading

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Citations

Sep 5, 2020·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·James VaissiereEske M Derks
Nov 13, 2019·Translational Psychiatry·Tilman HenschUlrich Hegerl
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Jul 23, 2021·Scientific Reports·Wikus BarkhuizenAngelica Ronald

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