Genome-wide association study of seasonal affective disorder

Translational Psychiatry
Kwo Wei David HoJames B Potash

Abstract

Family and twin studies have shown a genetic component to seasonal affective disorder (SAD). A number of candidate gene studies have examined the role of variations within biologically relevant genes in SAD susceptibility, but few genome-wide association studies (GWAS) have been performed to date. The authors aimed to identify genetic risk variants for SAD through GWAS. The authors performed a GWAS for SAD in 1380 cases and 2937 controls of European-American (EA) origin, selected from samples for GWAS of major depressive disorder and of bipolar disorder. Further bioinformatic analyses were conducted to examine additional genomic and biological evidence associated with the top GWAS signals. No susceptibility loci for SAD were identified at a genome-wide significant level. The strongest association was at an intronic variant (rs139459337) within ZBTB20 (odds ratio (OR) = 1.63, p = 8.4 × 10-7), which encodes a transcriptional repressor that has roles in neurogenesis and in adult brain. Expression quantitative trait loci (eQTL) analysis showed that the risk allele "T" of rs139459337 is associated with reduced mRNA expression of ZBTB20 in human temporal cortex (p = 0.028). Zbtb20 is required for normal murine circadian rhythm and fo...Continue Reading

References

Feb 1, 1990·Psychiatry Research·L N RosenN E Rosenthal
Aug 1, 1986·Acta Psychiatrica Scandinavica·A Wirz-JusticeB Woggon
Jan 1, 1996·Archives of General Psychiatry·P A MaddenN G Martin
Feb 13, 2002·American Journal of Medical Genetics·Ming-Ta TsaiChia-Hsiang Chen
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carolina JohanssonTimo Partonen
Jul 5, 2003·Science·Carol A DudleySteven L McKnight
Apr 1, 2005·The American Journal of Psychiatry·Robert N GoldenCharles B Nemeroff
Apr 6, 2006·BMC Genomics·Brandon W HiggsBeata Barci
Apr 10, 2007·Nature Neuroscience·Jason P DeBruyneSteven M Reppert
Apr 26, 2007·Annals of Medicine·Timo PartonenGunter Schumann
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Sep 23, 2008·Journal of Affective Disorders·Kathryn A RoeckleinIgnacio Provencio
Jun 3, 2010·The American Journal of Psychiatry·Alan R SandersPablo V Gejman
Jun 29, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eszter MolnarGyorgy Bagdy
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Jul 17, 2010·Bioinformatics·Randall J PruimCristen J Willer
Sep 20, 2011·Nature Genetics·UNKNOWN Psychiatric GWAS Consortium Bipolar Disorder Working Group
Dec 6, 2011·Nature Methods·Olivier DelaneauJean-François Zagury
Oct 3, 2013·Genome Biology·Carsten ReissnerMarkus Missler
Jul 16, 2014·Nature Genetics·Viviana CordedduRaoul C Hennekam
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Sep 1, 2014·Nature Neuroscience·Adaikalavan RamasamyMichael E Weale
Jan 7, 2015·The Journal of Clinical Psychiatry·Enda M ByrneTeodor T Postolache
Apr 28, 2018·Nature Genetics·Naomi R WrayUNKNOWN Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
ChIP-Seq

Software Mentioned

SNPTEST
SHAPEIT
LocusZoom
SimpleM
IMPUTE2
METAL

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Journal of Surgical Education
David R Farley
Gazette médicale de France
P PetitJ Roure
Journal of Palliative Care
David J Roy
The Harvard Mental Health Letter
© 2022 Meta ULC. All rights reserved