Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study.

Diabetes
Stephanie J LoomisElizabeth Selvin

Abstract

Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A1c (HbA1c) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide association studies of fructosamine and glycated albumin among 2,104 black and 7,647 white participants without diabetes in the Atherosclerosis Risk in Communities (ARIC) Study and replicated findings in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in RCN3, was associated with fructosamine (P = 5.3 × 10-9) and rs1260236, a known diabetes-related missense mutation in GCKR, was associated with percent glycated albumin (P = 5.9 × 10-9) and replicated in CARDIA. We also found two novel associations among blacks: an intergenic SNP, rs2438321, associated with fructosamine (P = 6.2 × 10-9), and an intronic variant in PRKCA, rs59443763, associated with percent glycated albumin (P = 4.1 × 10-9), but these results did not replicate. Few established fasting glucose or HbA1c SNPs were also associated with fructosamine or glycated albumin. Overall, we found genetic variants associated with the glycemic informatio...Continue Reading

References

Jan 1, 1988·Journal of Clinical Epidemiology·G D FriedmanP J Savage
Jun 19, 2007·Nature Genetics·Jonathan MarchiniPeter Donnelly
Mar 5, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bent Honoré
Mar 18, 2010·BMC Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Apr 13, 2010·Nature Genetics·Anna KöttgenCaroline S Fox
Jun 1, 2010·BMC Bioinformatics·Reedik Mägi, Andrew P Morris
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Aug 21, 2010·Endocrine Journal·Masafumi Koga, Soji Kasayama
Nov 9, 2010·Genetic Epidemiology·Yun LiGonçalo R Abecasis
Jan 29, 2011·Diabetes Care·David B Sacks
Mar 17, 2011·JAMA : the Journal of the American Medical Association·Katya B Rubinow, Irl B Hirsch
Nov 2, 2012·Clinical Chemistry·Robert M Cohen, David B Sacks
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Dec 20, 2012·Journal of Diabetes Investigation·Takeshi ArakiUNKNOWN Japanese Red Cross GA Research Group
Sep 25, 2014·Current Diabetes Reports·Christina M Parrinello, Elizabeth Selvin
Nov 29, 2014·Bioinformatics·Matthias ArnoldGabi Kastenmüller
Jan 17, 2015·Journal of Diabetes Science and Technology·Elisa DaneseGiuseppe Lippi
Jul 15, 2015·Human Molecular Genetics·Karen L Mohlke, Michael Boehnke
Sep 29, 2015·Nature Genetics·Brendan Bulik-SullivanBenjamin M Neale
Dec 3, 2016·Nucleic Acids Research·Jacqueline MacArthurHelen Parkinson
Jun 2, 2017·Diabetes·Robert A ScottUNKNOWN DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Oct 25, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xingxing HeWeiping Jia

❮ Previous
Next ❯

Citations

May 16, 2019·Journal of Diabetes Research·Matthew P JohnsonSarah Williams-Blangero
Jan 31, 2019·World Journal of Diabetes·Maja Krhač, Marijana Vučić Lovrenčić
Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xie SaiyangTang Qizhu

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

SNPTEST
Single Nucleotide Polymorphisms Annotator ( SNiPA )
IMPUTE2
EIGENSTRAT
MACH
LDSC
SAS
GWAMA
SNiPA
METAL

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.