Genome-wide association study of Stayability and Heifer Pregnancy in Red Angus cattle

Journal of Animal Science
S E SpeidelM G Thomas

Abstract

Reproductive performance is the most important component of cattle production from the standpoint of economic sustainability of commercial beef enterprises. Heifer Pregnancy (HPG) and Stayability (STAY) genetic predictions are 2 selection tools published by the Red Angus Association of America (RAAA) to assist with improvements in reproductive performance. Given the importance of HPG and STAY to the profitability of commercial beef enterprises, the objective of this study was to identify QTL associated with both HPG and STAY in Red Angus cattle. A genome-wide association study (GWAS) was performed using deregressed HPG and STAY EBV, calculated using a single-trait animal model and a 3-generation pedigree with data from the Spring 2015 RAAA National Cattle Evaluation. Each individual animal possessed 74,659 SNP genotypes. Individual animals with a deregressed EBV reliability > 0.05 were merged with the genotype file and marker quality control was performed. Criteria for sifting genotypes consisted of removing those markers where any of the following were found: average call rate less than 0.85, minor allele frequency < 0.01, lack of Hardy-Weinberg equilibrium (P < 0.0001), or extreme linkage disequilibrium (r2 > 0.99). These cri...Continue Reading

References

Apr 28, 2009·Genome Biology·Aleksey V ZiminSteven L Salzberg
Jan 2, 2010·Genetics, Selection, Evolution : GSE·Dorian J GarrickRohan L Fernando
May 25, 2011·BMC Bioinformatics·David HabierDorian J Garrick
Jan 1, 1983·Genetics, Selection, Evolution : GSE·D Gianola, J Foulley
Aug 15, 2012·BMC Genetics·Johanna K HöglundGoutam Sahana
Dec 12, 2012·Genetics, Selection, Evolution : GSE·Mahdi SaatchiDorian J Garrick
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·Yun-Fu LiuSong-Jia Lai
Sep 27, 2014·BMC Genetics·Priscila S N de OliveiraLuciana C A Regitano
Jul 23, 2015·Heart Failure Reviews·Lorna DanielsJeffrey R Erickson
Sep 1, 2015·BMC Genomics·Shiguo ZhouDavid C Schwartz
Jul 7, 2017·BMC Cancer·Olafur Andri StefanssonStefan Sigurdsson

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Citations

Jul 27, 2020·Translational Animal Science·Miguel A Sánchez-CastroScott E Speidel

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