Genome-wide association study of subclinical interstitial lung disease in MESA.

Respiratory Research
Ani ManichaikulDavid J Lederer

Abstract

We conducted a genome-wide association study (GWAS) of subclinical interstitial lung disease (ILD), defined as high attenuation areas (HAA) on CT, in the population-based Multi-Ethnic Study of Atherosclerosis Study. We measured the percentage of high attenuation areas (HAA) in the lung fields on cardiac CT scan defined as voxels with CT attenuation values between -600 and -250 HU. Genetic analyses were performed in MESA combined across race/ethnic groups: non-Hispanic White (n = 2,434), African American (n = 2,470), Hispanic (n = 2,065) and Chinese (n = 702), as well as stratified by race/ethnicity. Among 7,671 participants, regions at genome-wide significance were identified for basilar peel-core ratio of HAA in FLJ35282 downstream of ANRIL (rs7852363, P = 2.1x10-9) and within introns of SNAI3-AS1 (rs140142658, P = 9.6x10-9) and D21S2088E (rs3079677, P = 2.3x10-8). Within race/ethnic groups, 18 additional loci were identified at genome-wide significance, including genes related to development (FOXP4), cell adhesion (ALCAM) and glycosylation (GNPDA2, GYPC, GFPT1 and FUT10). Among these loci, SNP rs6844387 near GNPDA2 demonstrated nominal evidence of replication in analysis of n = 1,959 participants from the Framingham Heart Stu...Continue Reading

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Citations

Jun 25, 2019·Clinical and Translational Gastroenterology·Mark O GoodarziUNKNOWN Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Jul 25, 2019·American Journal of Respiratory and Critical Care Medicine·Brian D HobbsGary M Hunninghake
Jan 7, 2021·BMC Pulmonary Medicine·Gali Epstein ShochetDavid Shitrit
Mar 29, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jian ZhangZunfu Ke
Jul 9, 2021·Nature·UNKNOWN COVID-19 Host Genetics Initiative

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Methods Mentioned

BETA
genotyping
glycosylation
PCR

Software Mentioned

LocusZoom
MESA

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