Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort

Atherosclerosis
Gaoqiang XieYangfeng Wu

Abstract

Carotid artery intima media thickness (IMT) in human is a marker of subclinical atherosclerosis with high heritability. Many genome-wide association studies (GWAS) were performed in European and American populations, yet discovery efforts have been limited in Asians. To identify the genetic determinants of 10-year progression of IMT using GWA approach in a Chinese cohort. Cardiovascular epidemiologic survey was carried out in 810 Chinese adults in 2012. 302,218 single-nucleotide polymorphisms (SNP) in whole genome were genotyped using gene chip and carotid IMT was measured. Most of these participants, had previous carotid IMT measurements in 2002 (n = 572), 2005 (n = 750), 2007 (n = 747), and 2010 (n = 671). General linear model (GLM) and multiple linear mixed-model (MLM) were used to assess the association between SNPs and carotid IMT. The mean age (SD) of the sample was 61.3 (5.1) years; 33.6% were men. The adjusted GLM showed no SNP with significance association at genome-level (all p > 1 × 10(-7)). However, using MLM, after adjusting for age, sex, number of cigarettes smoked per day, systolic blood pressure, use of antihypertensive drugs in the past 2 weeks, serum cholesterol, body mass index, fasting glucose levels, use of...Continue Reading

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Citations

Jan 26, 2017·Scientific Reports·Maria S NazarenkoValery P Puzyrev
Jul 7, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Bianka ForgoAdam Domonkos Tarnoki
Sep 7, 2017·The New England Journal of Medicine·Ge ZhangLouis J Muglia
Nov 23, 2019·Genes·Paula Costa-UrrutiaMartha Eunice Rodríguez-Arellano
Jun 23, 2018·Frontiers in Cardiovascular Medicine·Wolfgang Lieb, Ramachandran S Vasan
Jun 28, 2018·Molecular Neurobiology·Wu ChenXin Wang
May 13, 2020·Journal of the American Heart Association·Vyacheslav A KorshunovBradford C Berk
Mar 19, 2021·Immunometabolism·Michael J Griffin
Nov 11, 2018·Seminars in Nephrology·Joseph Lunyera, Julia J Scialla

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