Genome-wide association study provides insights into genes related with horn development in Nelore beef cattle

PloS One
Nedenia Bonvino StafuzzaFernando Baldi

Abstract

The causal mutation for polledness in Nelore (Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds; however, the genetic basis of this trait in indicine cattle is still unclear. The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631-3,987,104 bp) was found to be associated with hornless in the studied population. A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell med...Continue Reading

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Citations

Jun 11, 2019·Animal Genetics·A H Falomir-LockhartG Giovambattista
Apr 28, 2020·Biological Reviews of the Cambridge Philosophical Society·Alireza Nasoori
Jan 16, 2019·Animal Genetics·Yuri Tani UtsunomiyaJosé Fernando Garcia
Sep 6, 2020·Genetics, Selection, Evolution : GSE·Seyed Mohammad GhoreishifarArash Javanmard
Feb 10, 2021·BMC Genomics·Maulana M NajiGábor Mészáros

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Methods Mentioned

BETA
nucleotide exchange

Software Mentioned

CLARIFIDE
THRGIBBS1F90
Ensembl BioMart
ssGBLUP
WssGWAS
postGSf90
DAVID
PLINK

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