Genome-wide association study reveals novel genes for the ear size in sheep (Ovis aries)

Animal Genetics
L GaoM-H Li

Abstract

Variations in ear size can be observed in livestock such as sheep; however, the genetic basis of variable ear size in sheep is still poorly understood. To investigate causative genes associated with ear size in sheep, a genome-wide association study was performed in 115 adult Duolang sheep with different-sized floppy ears using the Ovine Infinium HD BeadChip. We found 38 significant SNPs at the genome-wide or chromosome-wise 5% significance level after Bonferroni correction. The most significant association (P = 1.61 × 10-6 ) was found at SNP rs402740419, located in the DCC gene, which plays a critical role in ear development. Also, we observed two additional significant SNPs, rs407891215 in PTPRD and rs407769095 in SOX5, both of which are functionally associated with ear developmental processes. Our results are useful for future sheep breeding and provide insights into the genetic basis of ear size development in sheep and other livestock.

References

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Mar 19, 2009·Journal of Medical Genetics·F Alasti, G Van Camp
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Citations

Jun 18, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Salvatore MastrangeloFabio Pilla
Feb 15, 2019·Genetics, Selection, Evolution : GSE·Claire OgetRachel Rupp
Jan 25, 2020·The Journal of Craniofacial Surgery·Meng LuBo Pan
Jun 3, 2020·Genes·Khaleel I Z Jawasreh, Haitham Daif-Allah Al-Omari
Aug 18, 2020·Animal Genetics·J M ParisC Drögemüller
Sep 8, 2021·Frontiers in Genetics·Zhong-Huang WangMeng-Hua Li

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