Genome-wide association study reveals sex-specific selection signals against autosomal nucleotide variants

Journal of Human Genetics
Dongchan RyuChaeyoung Lee

Abstract

A genome-wide association study (GWAS) was conducted to examine genetic associations of common autosomal nucleotide variants with sex in a Korean population with 4183 males and 4659 females. Nine genetic association signals were identified in four intragenic and five intergenic regions (P<5 × 10(-8)). Further analysis with an independent data set confirmed two intragenic association signals in the genes encoding protein phosphatase 1, regulatory subunit 12B (PPP1R12B, intron 12, rs1819043) and dynein, axonemal, heavy chain 11 (DNAH11, intron 61, rs10255013), which are directly involved in the reproductive system. This study revealed autosomal genetic variants associated with sex ratio by GWAS for the first time. This implies that genetic variants in proximity to the association signals may influence sex-specific selection and contribute to sex ratio variation. Further studies are required to reveal the mechanisms underlying sex-specific selection.

References

Jul 23, 1998·Biology of Reproduction·P E Visconti, G S Kopf
Apr 30, 2002·Lancet·Misao FukudaAnne Grete Byskov
Apr 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Oct 6, 2005·Environmental Health Perspectives·Constanze A MackenzieMargaret Keith
Nov 4, 2005·Bioinformatics·Nusrat Rabbee, Terence P Speed
Jun 26, 2007·Asian Journal of Andrology·Rumela ChakrabartiSrinivasan Vijayaraghavan
Jul 17, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Margaret W LeighMaimoona A Zariwala
Feb 5, 2010·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Libin DengYan Wang
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Sep 6, 2011·Nature Methods·Christoph LippertDavid Heckerman
Dec 21, 2011·Thorax·Michael R KnowlesUNKNOWN Genetic Disorders of Mucociliary Clearance Consortium
Jul 31, 2012·Human Molecular Genetics·Vesna BoraskaEleftheria Zeggini
Mar 14, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Younyoung KimChaeyoung Lee

❮ Previous
Next ❯

Citations

Jan 11, 2017·Medicine·Dongchan Ryu, Chaeyoung Lee
Jan 26, 2018·Journal of Bioethical Inquiry·Arianne Shahvisi
Apr 24, 2021·Nature Genetics·Nicola PirastuAndrea Ganna
Aug 9, 2020·Current Biology : CB·Erping Long, Jianzhi Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved