Apr 30, 2020

Resting-State Functional Connectivity Predicts Individual Pain Ratings to a Tonic Orofacial Pain Stimulus

BioRxiv : the Preprint Server for Biology
L. J. AyoubMassieh Moayedi


Pain is a subjective experience with significant individual differences. Laboratory studies investigating pain thresholds and acute pain have identified structural and functional neural correlates. However, these types of pain stimuli have limited ecological validity to real-life pain experience. Here, we use an orthodontic procedure which typically induces pain lasting several days. We aimed to determine whether the baseline structure and resting-state functional connectivity (rsFC) of key regions along the trigeminal nociceptive and pain modulatory pathways correlate with subsequent peak pain ratings. Twenty-six healthy individuals underwent structural (T1, diffusion-weighted MRI) and resting-state functional magnetic resonance imaging (rs-fMRI) scanning prior to the orthodontic procedure, the insertion of an elastomeric separator between teeth, for five days. Participants recorded pain ratings three times, daily. Peak pain was not correlated with structural measures for the trigeminal nerve or any brain region. However, peak pain correlated with rsFC between the contralateral thalamus and bilateral insula, and negatively correlated with connectivity between the periaqueductal gray and core nodes of the default mode network (...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Genome-Wide Association Study
Biochemical Pathway
Animal Cancer Model
Gene Mutation
Cancer Treatment
Monitoring Procedure

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.