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Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma

Laboratory Investigation; a Journal of Technical Methods and Pathology

Feb 23, 2018

Weijian SunShusen Zheng

Abstract

The genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen is a powerful tool used to identify therapeutic targets that can be harnessed for cancer treatment. This study aimed to assess the efficacy of genome-wide CRISPR screening to identify druggable gen...read more

Mentioned in this Paper

Genome-Wide Association Study
SGOL1 protein, human
Study
In Vivo
Subfamily lentivirinae
Antineoplastic Agents
Antibiotic Resistance, Neoplasm
Gene Knockdown Techniques
Cell Cycle Proteins
Mice, Inbred BALB C
6
33
Paper Details
References
  • References27
  • Citations1
123
  • References27
  • Citations1
1

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Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma

Laboratory Investigation; a Journal of Technical Methods and Pathology

Feb 23, 2018

Weijian SunShusen Zheng

PMID: 29467456

DOI: 10.1038/s41374-018-0027-6

Abstract

The genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen is a powerful tool used to identify therapeutic targets that can be harnessed for cancer treatment. This study aimed to assess the efficacy of genome-wide CRISPR screening to identify druggable gen...read more

Mentioned in this Paper

Genome-Wide Association Study
SGOL1 protein, human
Study
In Vivo
Subfamily lentivirinae
Antineoplastic Agents
Antibiotic Resistance, Neoplasm
Gene Knockdown Techniques
Cell Cycle Proteins
Mice, Inbred BALB C
6
33

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CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.

Detecting CRISPR Off-Targets

CRISPR-Cas system enables the editing of genes to create or correct mutations. However, its high frequency of off-target activity is a major concern, especially for therapeutic and clinical applications. This feed focuses on methods that can detect CRISPR off-target activity.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

Proceedings of the National Academy of Sciences of the United States of AmericaOctober 13, 2016
Van Trung ChuKlaus Rajewsky
Science

Genome-scale CRISPR-Cas9 knockout screening in human cells

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Paper Details
References
  • References27
  • Citations1
123
  • References27
  • Citations1
1
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