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Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma

Laboratory Investigation; a Journal of Technical Methods and Pathology

Jun 21, 2018

Wei-Jian SunShu-Sen Zheng

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Abstract

The genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen is a powerful tool used to identify therapeutic targets that can be harnessed for cancer treatment. This study aimed to assess the efficacy of genome-wide CRISPR screening to identify druggable gen...read more

Mentioned in this Paper

Antineoplastic Agents
Genes
Genome
Metabolic Inhibition
Mice, Inbred BALB C
RNA
deoxy(thymidylyl-cytidylyl-guanylyl-adenylic acid)
Genus: Lentivirus group
RNA, Guide
Cell Line, Tumor
5
26
Paper Details
References
    • References27
    • Citations
    • References27
    • Citations

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      This paper may not have been cited yet.
  • Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma

    Laboratory Investigation; a Journal of Technical Methods and Pathology

    Jun 21, 2018

    Wei-Jian SunShu-Sen Zheng

    PMID: 29467456

    DOI: 10.1038/s41374-018-0027-6

    Abstract

    The genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen is a powerful tool used to identify therapeutic targets that can be harnessed for cancer treatment. This study aimed to assess the efficacy of genome-wide CRISPR screening to identify druggable gen...read more

    Mentioned in this Paper

    Antineoplastic Agents
    Genes
    Genome
    Metabolic Inhibition
    Mice, Inbred BALB C
    5
    26
    Paper Details
    References
    • References27
    • Citations
    • References27
    • Citations

      No citations available

      This paper may not have been cited yet.
  • Get paper from

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