Genome-wide diversity and global migration patterns in dromedaries follow ancient caravan routes.

Communications Biology
Sara LadoPamela A Burger

Abstract

Dromedaries have been essential for the prosperity of civilizations in arid environments and the dispersal of humans, goods and cultures along ancient, cross-continental trading routes. With increasing desertification their importance as livestock species is rising rapidly, but little is known about their genome-wide diversity and demographic history. As previous studies using few nuclear markers found weak phylogeographic structure, here we detected fine-scale population differentiation in dromedaries across Asia and Africa by adopting a genome-wide approach. Global patterns of effective migration rates revealed pathways of dispersal after domestication, following historic caravan routes like the Silk and Incense Roads. Our results show that a Pleistocene bottleneck and Medieval expansions during the rise of the Ottoman empire have shaped genome-wide diversity in modern dromedaries. By understanding subtle population structure we recognize the value of small, locally adapted populations and appeal for securing genomic diversity for a sustainable utilization of this key desert species.

References

Dec 9, 2003·Molecular Biology and Evolution·David Bryant, Vincent Moulton
Oct 14, 2005·Molecular Biology and Evolution·Daniel H Huson, David Bryant
May 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Albano Beja-PereiraGiorgio Bertorelle
Jun 27, 2006·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Aleksandr MorgulisRicha Agarwala
Oct 25, 2008·BMC Evolutionary Biology·Joseph Heled, Alexei J Drummond
Mar 10, 2009·PloS One·James W KijasUNKNOWN International Sheep Genomics Consortium
Aug 4, 2009·Genome Research·David H AlexanderKenneth Lange
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
Jun 10, 2011·Bioinformatics·Petr DanecekUNKNOWN 1000 Genomes Project Analysis Group
May 25, 2013·Molecular Ecology·Julian CatchenWilliam A Cresko
Oct 15, 2013·Molecular Ecology·Vera M WarmuthAndrea Manica
Jun 13, 2014·Proceedings. Biological Sciences·Emiliano TrucchiCéline Le Bohec
Oct 9, 2014·Frontiers in Genetics·Sithembile O MakinaAzwihangwisi Maiwashe
Jul 17, 2015·Molecular Ecology Resources·Robert R FitakPamela A Burger
Nov 28, 2015·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·A GurgulM Bugno-Poniewierska
Dec 8, 2015·Nature Genetics·Desislava PetkovaMatthew Stephens
Apr 7, 2016·Tropical Animal Health and Production·Pamela Anna Burger
May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Faisal AlmathenPamela A Burger
Mar 24, 2018·Genetics, Selection, Evolution : GSE·Otsanda Ruiz-LarrañagaAndone Estonba
May 11, 2018·Science·Peter de Barros DamgaardEske Willerslev
Apr 9, 2019·PLoS Computational Biology·Remco BouckaertAlexei J Drummond
Apr 12, 2019·Molecular Ecology Resources·Jean P ElbersPamela A Burger

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCA

Software Mentioned

VCFTOOLS
EBSP
IGA
Arlequin
EEMS
pstack
Adegenet
Google Maps API Tool
dustmasker
MEM

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.