Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

Clinical Epigenetics
Mi Kyeong LeeStephanie J London

Abstract

Ambient air pollution is associated with numerous adverse health outcomes, but the underlying mechanisms are not well understood; epigenetic effects including altered DNA methylation could play a role. To evaluate associations of long-term air pollution exposure with DNA methylation in blood, we conducted an epigenome-wide association study in a Korean chronic obstructive pulmonary disease cohort (N = 100 including 60 cases) using Illumina's Infinium HumanMethylation450K Beadchip. Annual average concentrations of particulate matter ≤ 10 μm in diameter (PM10) and nitrogen dioxide (NO2) were estimated at participants' residential addresses using exposure prediction models. We used robust linear regression to identify differentially methylated probes (DMPs) and two different approaches, DMRcate and comb-p, to identify differentially methylated regions (DMRs). After multiple testing correction (false discovery rate < 0.05), there were 12 DMPs and 27 DMRs associated with PM10 and 45 DMPs and 57 DMRs related to NO2. DMP cg06992688 (OTUB2) and several DMRs were associated with both exposures. Eleven DMPs in relation to NO2 confirmed previous findings in Europeans; the remainder were novel. Methylation levels of 39 DMPs were associated...Continue Reading

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Citations

Jan 15, 2020·Environmental Science and Pollution Research International·Qing ChangYuhong Zhao
Jun 2, 2020·International Journal of Environmental Health Research·Feifei FengYue Ba
Sep 1, 2019·Clinical Epigenetics·L FerrariV Bollati
Mar 17, 2020·Journal of the American Heart Association·Juyong Brian KimKari C Nadeau
Jul 2, 2019·Environmental Research·Sergi Sayols-BaixerasRoberto Elosua
Aug 7, 2019·Environment International·Alexandra J WhiteDale P Sandler
Jan 23, 2021·International Journal of Environmental Research and Public Health·Sahana Mathiarasan, Anke Hüls
Mar 28, 2021·Environmental Science and Pollution Research International·Sha LiJiahu Hao
Apr 6, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Gloria C ChiJoel D Kaufman
Apr 17, 2021·Environment International·Rongbin XuYuming Guo
Apr 24, 2021·Environmental Research·Álvaro Del RealM Teresa Zarrabeitia
Sep 14, 2021·Environmental Health Perspectives·Thanh T HoangStephanie J London

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Methods Mentioned

BETA
methylation profiling
chip

Software Mentioned

METAL
coMET R package
- Xr
ReGions
DMRcate
minfi R
DMRcate R package
R
eFORGE
GeoCoder

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