Genome-wide expression profiling shows transcriptional reprogramming in Fusarium graminearum by Fusarium graminearum virus 1-DK21 infection.

BMC Genomics
Won Kyong ChoKook-Hyung Kim

Abstract

Fusarium graminearum virus 1 strain-DK21 (FgV1-DK21) is a mycovirus that confers hypovirulence to F. graminearum, which is the primary phytopathogenic fungus that causes Fusarium head blight (FHB) disease in many cereals. Understanding the interaction between mycoviruses and plant pathogenic fungi is necessary for preventing damage caused by F. graminearum. Therefore, we investigated important cellular regulatory processes in a host containing FgV1-DK21 as compared to an uninfected parent using a transcriptional approach. Using a 3'-tiling microarray covering all known F. graminearum genes, we carried out genome-wide expression analyses of F. graminearum at two different time points. At the early point of growth of an infected strain as compared to an uninfected strain, genes associated with protein synthesis, including ribosome assembly, nucleolus, and ribosomal RNA processing, were significantly up-regulated. In addition, genes required for transcription and signal transduction, including fungal-specific transcription factors and cAMP signaling, respectively, were actively up-regulated. In contrast, genes involved in various metabolic pathways, particularly in producing carboxylic acids, aromatic amino acids, nitrogen compoun...Continue Reading

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Citations

Jul 9, 2014·Annual Review of Phytopathology·Jiatao Xie, Daohong Jiang
Nov 6, 2015·PLoS Pathogens·Moonil SonKook-Hyung Kim
Aug 1, 2019·FEMS Microbiology Ecology·Suvi SutelaEeva J Vainio
Aug 10, 2019·Phytopathology·Maria D D García-PedrajasJosé Sebastián Dambolena
Oct 6, 2018·Environmental Microbiology·L NervaM Turina
Nov 29, 2016·Frontiers in Microbiology·Jie ZhongQian Zhou
Mar 28, 2019·Frontiers in Cellular and Infection Microbiology·Almudena Torres-TrenasEncarnación Pérez-Artés
Aug 6, 2019·Frontiers in Cellular and Infection Microbiology·Pengfei LiLihua Guo

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Datasets Mentioned

BETA
GSE30545

Methods Mentioned

BETA
chips
chip
PCR

Software Mentioned

limma
BlastP
Acuity
lmFit
Bio
eBayes
FunCat
R
NimbleScan
Rad CFX Manager

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