Genome-wide gene expression array identifies novel genes related to disease severity and excessive daytime sleepiness in patients with obstructive sleep apnea

PloS One
Yung-Che ChenChang-Chun Hsiao

Abstract

We aimed to identify novel molecular associations between chronic intermittent hypoxia with re-oxygenation and adverse consequences in obstructive sleep apnea (OSA). We analyzed gene expression profiles of peripheral blood mononuclear cells from 48 patients with sleep-disordered breathing stratified into four groups: primary snoring (PS), moderate to severe OSA (MSO), very severe OSA (VSO), and very severe OSA patients on long-term continuous positive airway pressure treatment (VSOC). Comparisons of the microarray gene expression data identified eight genes up-regulated with OSA and down-regulated with CPAP treatment, and five genes down-regulated with OSA and up-regulated with CPAP treatment. Protein expression levels of two genes related to endothelial tight junction (AMOT P130, and PLEKHH3), and three genes related to anti-or pro-apoptosis (BIRC3, ADAR1 P150, and LGALS3) were all increased in the VSO group, while AMOT P130 was further increased, and PLEKHH3, BIRC3, and ADAR1 P150 were all decreased in the VSOC group. Subgroup analyses revealed that AMOT P130 protein expression was increased in OSA patients with excessive daytime sleepiness, BIRC3 protein expression was decreased in OSA patients with hypertension, and LGALS3 ...Continue Reading

References

Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Nov 25, 2004·Experimental Cell Research·Mélanie DuneauAlain Legrand
Jul 27, 2005·The Journal of Biological Chemistry·Anders BrattLars Holmgren
Apr 28, 2006·The FEBS Journal·Mira ErnkvistLars Holmgren
May 22, 2007·Antioxidants & Redox Signaling·Michal S HoffmannVirend K Somers
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Sep 2, 2009·Molecular and Cellular Biology·Lluis MartorellJosé Martínez-González
Jan 9, 2010·Biochemical and Biophysical Research Communications·Pauline RobinetAlain Legrand
Jan 23, 2010·American Journal of Respiratory and Critical Care Medicine·Abdelnaby KhalyfaDavid Gozal
Sep 28, 2010·American Journal of Respiratory Cell and Molecular Biology·Larissa DyugovskayaLena Lavie
May 25, 2012·Acta Oto-laryngologica·Chang Myeon SongJeong-Whun Kim
May 24, 2012·JAMA : the Journal of the American Medical Association·José M MarinSanja Jelic
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
May 21, 2014·Tissue Barriers·Serge PaschoudSandra Citi
Jun 7, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cyril X GeorgeCharles E Samuel
Dec 9, 2014·Small GTPases·Sandra CitiJimit Shah
Jan 22, 2015·Sleep & Breathing = Schlaf & Atmung·Yung-Che ChenMeng-Chih Lin
Apr 11, 2015·Frontiers in Bioengineering and Biotechnology·Giovanni NigitaAlfredo Ferro

❮ Previous
Next ❯

Citations

Dec 21, 2017·Frontiers in Neurology·Alberto R RamosDouglas M Wallace
Jul 17, 2018·American Journal of Respiratory and Critical Care Medicine·Colin E Sullivan
May 6, 2020·Sleep·Aditya AmbatiShahrad Taheri
Aug 11, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Luana ConteMichele De Benedetto
Jun 19, 2019·International Journal of Molecular Sciences·Yung-Che ChenMeng-Chih Lin
Oct 4, 2020·The European Respiratory Journal·Maria R BonsignoreWalter T McNicholas
Apr 23, 2021·Journal of Oncology·Donato LacedoniaMaria Pia Foschino Barbaro
Jul 31, 2021·Sleep Medicine Clinics·Walter T McNicholas
Jun 29, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Brittany A LeaderDavid F Smith

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
Protein Assay
ELISA
deamination

Software Mentioned

SPSS
GeneSpring
BeadStudio

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Related Papers

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
Judith L ReishteinMultisite Study group
JAMA : the Journal of the American Medical Association
Jose M MarínSanja Jelic
International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
O RestaG De Pergola
© 2022 Meta ULC. All rights reserved