Abstract
We aimed to identify novel molecular associations between chronic intermittent hypoxia with re-oxygenation and adverse consequences in obstructive sleep apnea (OSA). We analyzed gene expression profiles of peripheral blood mononuclear cells from 48 patients with sleep-disordered breathing stratified into four groups: primary snoring (PS), moderate to severe OSA (MSO), very severe OSA (VSO), and very severe OSA patients on long-term continuous positive airway pressure treatment (VSOC). Comparisons of the microarray gene expression data identified eight genes up-regulated with OSA and down-regulated with CPAP treatment, and five genes down-regulated with OSA and up-regulated with CPAP treatment. Protein expression levels of two genes related to endothelial tight junction (AMOT P130, and PLEKHH3), and three genes related to anti-or pro-apoptosis (BIRC3, ADAR1 P150, and LGALS3) were all increased in the VSO group, while AMOT P130 was further increased, and PLEKHH3, BIRC3, and ADAR1 P150 were all decreased in the VSOC group. Subgroup analyses revealed that AMOT P130 protein expression was increased in OSA patients with excessive daytime sleepiness, BIRC3 protein expression was decreased in OSA patients with hypertension, and LGALS3 ...Continue Reading
References
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Nov 25, 2004·Experimental Cell Research·Mélanie DuneauAlain Legrand
Jul 27, 2005·The Journal of Biological Chemistry·Anders BrattLars Holmgren
Apr 28, 2006·The FEBS Journal·Mira ErnkvistLars Holmgren
May 22, 2007·Antioxidants & Redox Signaling·Michal S HoffmannVirend K Somers
Nov 17, 2007·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Feb 12, 2008·Sleep Medicine·Abdelnaby KhalyfaDavid Gozal
Jun 24, 2009·The Journal of Physiology·Emilie RoudierOlivier Birot
Sep 2, 2009·Molecular and Cellular Biology·Lluis MartorellJosé Martínez-González
Jan 9, 2010·Biochemical and Biophysical Research Communications·Pauline RobinetAlain Legrand
Jan 23, 2010·American Journal of Respiratory and Critical Care Medicine·Abdelnaby KhalyfaDavid Gozal
Sep 28, 2010·American Journal of Respiratory Cell and Molecular Biology·Larissa DyugovskayaLena Lavie
Apr 13, 2011·Cancer Cell·Chunling YiJoseph L Kissil
May 25, 2012·Acta Oto-laryngologica·Chang Myeon SongJeong-Whun Kim
May 24, 2012·JAMA : the Journal of the American Medical Association·José M MarinSanja Jelic
Jun 26, 2012·FEBS Letters·Klaus Scheffzek, Stefan Welti
Oct 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard B BerryUNKNOWN American Academy of Sleep Medicine
Oct 24, 2012·Journal of Translational Medicine·Larissa DyugovskayaLena Lavie
Mar 2, 2013·PloS One·Yung-Che ChenMeng-Chih Lin
Aug 24, 2013·Journal of Hypertension·Rosa M BrunoLorenzo Ghiadoni
May 21, 2014·Tissue Barriers·Serge PaschoudSandra Citi
Jun 7, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cyril X GeorgeCharles E Samuel
Dec 9, 2014·Small GTPases·Sandra CitiJimit Shah
Jan 22, 2015·Sleep & Breathing = Schlaf & Atmung·Yung-Che ChenMeng-Chih Lin
Jan 22, 2015·Oncotarget·Yi XiaJian-Yong Li
Jan 31, 2015·Cell Death and Differentiation·J M CalandriaN G Bazan
Jan 31, 2015·Journal of Breath Research·M CorradiA Mutti
Apr 11, 2015·Frontiers in Bioengineering and Biotechnology·Giovanni NigitaAlfredo Ferro
Apr 16, 2015·Respiratory Care·Huajun XuShankai Yin
Apr 29, 2015·Nature and Science of Sleep·Poul JennumJakob Kjellberg
Jun 3, 2015·Journal of Neurochemistry·Magdalena ZaniewskaMałgorzata Filip
Citations
Dec 21, 2017·Frontiers in Neurology·Alberto R RamosDouglas M Wallace
Jul 17, 2018·American Journal of Respiratory and Critical Care Medicine·Colin E Sullivan
May 6, 2020·Sleep·Aditya AmbatiShahrad Taheri
Aug 11, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Luana ConteMichele De Benedetto
Jun 19, 2019·International Journal of Molecular Sciences·Yung-Che ChenMeng-Chih Lin
Oct 22, 2019·Respiratory Investigation·Saif Mashaqi, David Gozal
Oct 4, 2020·The European Respiratory Journal·Maria R BonsignoreWalter T McNicholas
Mar 11, 2021·BioMed Research International·Yuanyuan CaoNanfang Li
Apr 23, 2021·Journal of Oncology·Donato LacedoniaMaria Pia Foschino Barbaro
Jul 31, 2021·Sleep Medicine Clinics·Walter T McNicholas
Jun 29, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Brittany A LeaderDavid F Smith