Genome-wide genetic investigation of serological measures of common infections

European Journal of Human Genetics : EJHG
Rohina RubiczHarald H H Göring

Abstract

Populations and individuals differ in susceptibility to infections because of a number of factors, including host genetic variation. We previously demonstrated that differences in antibody titer, which reflect infection history, are significantly heritable. Here we attempt to identify the genetic factors influencing variation in these serological phenotypes. Blood samples from >1300 Mexican Americans were quantified for IgG antibody level against 12 common infections, selected on the basis of their reported role in cardiovascular disease risk: Chlamydia pneumoniae; Helicobacter pylori; Toxoplasma gondii; cytomegalovirus; herpes simplex I virus; herpes simplex II virus; human herpesvirus 6 (HHV6); human herpesvirus 8 (HHV8); varicella zoster virus; hepatitis A virus (HAV); influenza A virus; and influenza B virus. Pathogen-specific quantitative antibody levels were analyzed, as were three measures of pathogen burden. Genome-wide linkage and joint linkage and association analyses were performed using ~1 million SNPs. Significant linkage (lod scores >3.0) was obtained for HHV6 (on chromosome 7), HHV8 (on chromosome 6), and HAV (on chromosome 13). SNP rs4812712 on chromosome 20 was significantly associated with C. pneumoniae (P=5.3...Continue Reading

References

Jul 1, 1977·Annals of Human Genetics·M A SpenceK Lange
Aug 1, 1986·Journal of Biochemical and Biophysical Methods·M L ChengJ L VandeBerg
Mar 1, 1996·Journal of Virology·K N FishJ A Nelson
Oct 27, 1997·American Journal of Human Genetics·S C Heath
Dec 10, 1997·The American Journal of Tropical Medicine and Hygiene·S Williams-BlangeroA R Teixeira
Jan 1, 1997·Genetic Epidemiology·S C HeathE M Wijsman
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S E EpsteinD Hajjar
Aug 24, 2000·The American Journal of Cardiology·J ZhuS E Epstein
Apr 21, 2001·Biometrics·B Devlin, K Roeder
Jan 5, 2002·Circulation·Christine Espinola-KleinUNKNOWN AtheroGene Investigators
Jan 10, 2006·American Journal of Human Genetics·Sobha PuppalaRavindranath Duggirala
Apr 7, 2007·The Pediatric Infectious Disease Journal·Nicola P KleinUNKNOWN Clinical Immunization Safety Assessment Network
Apr 30, 2010·Journal of Virology·Chad M SwansonMichael H Malim
Oct 27, 2010·Paediatrics & Child Health·Robert M JacobsonGregory A Poland
Jan 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ping ZhanYong Song
Oct 15, 2011·Human Heredity·Rohina RubiczHarald H H Göring
Nov 8, 2012·The Journal of Pathology·Michal Cohen-EliavRotem Karni
Jun 26, 2013·Reviews in Medical Virology·Howard Newman, Caroline Gooding

❮ Previous
Next ❯

Citations

Jul 29, 2018·Genome Medicine·Petar ScepanovicUNKNOWN Milieu Intérieur Consortium
Aug 28, 2015·Genes and Immunity·H SungC S Rabkin
Jun 10, 2020·Bulletin of the World Health Organization·Charlotte JamesKatharine J Looker
Sep 6, 2020·International Journal of Molecular Sciences·Tatsuo KandaMitsuhiko Moriyama
Aug 10, 2019·Frontiers in Genetics·Efe SezginCheryl A Winkler
Jan 1, 2018·Cancer Treatment and Research Communications·Wendy Innis-WhitehouseMegan Keniry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.