Genome-wide linkage analysis for hypospadias susceptibility genes

The Journal of Urology
Louise FrisénAgneta Nordenskjöld

Abstract

Hypospadias, when the urethra opens on the underside of the penis, is a common malformation that occurs in about 1/300 boys. The etiology of hypospadias is unknown but several lines of evidence indicate that it is caused by the combined influence of genetic and environmental factors. To identify chromosomal loci involved in the pathogenesis of hypospadias we performed genome-wide linkage analysis. A total of 69 families with at least 2 members with hypospadias were genotyped with 360 microsatellite markers and analyzed with a nonparametric affected relative pair method. Of them 58 were of Swedish origin and 11 were from the Middle East. Suggestive linkage was found at the 4 chromosome regions 9q22 (in all families), 2p11, 10p15 and 10q21 (in Swedish families). These results provide a basis for outlining the genetic background of hypospadias.

References

May 1, 1985·American Journal of Medical Genetics·M FrydmanH A Cohen
Mar 7, 1998·American Journal of Human Genetics·M Ehm, M Wagner
Nov 17, 1998·The Journal of Urology·L FredellA Nordenskjöld
Mar 25, 1999·Environmental Health Perspectives·L J Paulozzi
Jul 13, 1999·Epidemiology·O AkreA Ekbom
Jul 13, 1999·Epidemiology·J B Klotz, L A Pyrch
May 10, 2000·Nature Genetics·D F GudbjartssonA Kong
May 29, 2000·American Journal of Human Genetics·E R MartinN L Kaplan
Jul 8, 2000·American Journal of Human Genetics·D R Nyholt
Jun 1, 2001·Nature·J A Todd
Feb 8, 2002·The Journal of Urology·Louise FredellAneta Nordenskjöld
Apr 16, 2002·Nature Genetics·Stacey B GabrielAravinda Chakravarti
Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith

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Citations

Jul 29, 2008·Human Genetics·Hanh T T ThaiAgneta Nordenskjöld
Mar 23, 2007·European Journal of Human Genetics : EJHG·Jorge AndradeJacob Odeberg
Mar 1, 2012·Human Reproduction Update·L F M van der ZandenN Roeleveld
Jan 12, 2010·The Journal of Sexual Medicine·Fumihiro SataReiko Kishi
May 24, 2006·Pediatric Clinics of North America·Dawn L MacLellan, David A Diamond
Jul 1, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lei JinAiguo Ren
Jul 6, 2014·European Journal of Human Genetics : EJHG·Cilla SöderhällAgneta Nordenskjöld
Sep 22, 2018·Journal of Cellular Physiology·Marjan JoodiAmir Avan
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Hanh T T ThaiAgneta Nordenskjöld
Mar 24, 2006·Journal of Endocrinological Investigation·A Beleza-MeirelesA Nordenskjöld

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