Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart Study

Human Genetics
Donna K ArnettJ H Eckfeldt

Abstract

Recent reports implicate chromosomal regions linked to inter-individual variation in plasma triglycerides. We conducted genome-wide scans to replicate these linkages and/or identify other loci influencing plasma triglycerides in the NHLBI Family Heart Study (FHS). Data were obtained for 501 three-generational families. Genotyping was done by the Utah Molecular Genetics Laboratory and NHLBI Mammalian Genotyping Service; markers from both were placed on one genetic map. Analysis was done using multipoint variance components linkage. Fasting plasma triglycerides were log-transformed and age-, sex-, and field center-adjusted; suggestive linkage evidence was found on chromosome 8 (LOD=2.80 at 89 cM, marker D8S1141). Further adjustment for waist girth, BMI, diabetes, hypertension, and lipid-lowering drugs suggested linkage regions on chromosomes 6 (LOD=2.29 at 79 cM, marker D6S295) and 15 (LOD=1.85 at 43 cM, marker D15S659). Since HDL is correlated with triglycerides and because it was linked to this region on chromosome 15 in FHS, we created a composite triglyceride-HDL phenotype. The combined phenotype LOD score was 3.0 at the same marker on chromosome 15. Chromosome 15 likely harbors a susceptibility locus with an influence on tri...Continue Reading

Associated Clinical Trials

References

Jun 15, 1996·American Journal of Epidemiology·M HigginsR Williams
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·L PérusseC Bouchard
Jan 1, 1997·Genetic Epidemiology·D K ArnettT A Sellers
Mar 11, 2000·American Journal of Human Genetics·S C PrattL Kruglyak
Oct 19, 2000·Advances in Genetics·J L Weber, K W Broman
Apr 11, 2001·Journal of the American College of Nutrition·P M SuterE Hänseler
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T ShojiY Nishizawa
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Sep 23, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Rossitza P NaoumovaCarol C Shoulders

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Citations

Aug 1, 2008·Genetica·Laura Almasy, John Blangero
Mar 16, 2005·Current Opinion in Lipidology·Xiaosong Wang, Beverly Paigen
Feb 5, 2008·Journal of Lipid Research·Sara Bretschger SeidelmannQing Kenneth Wang

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