Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12

Human Genetics
Ethan M LangeKathleen A Cooney

Abstract

Epidemiological and twin studies have consistently demonstrated a strong genetic component to prostate cancer (PCa) susceptibility. To date, numerous linkage studies have been performed to identify chromosomal regions containing PCa susceptibility genes. Unfortunately, results from these studies have failed to form any obvious consensus regarding which regions are most likely to contain genes that may contribute to PCa predisposition. One plausible explanation for the difficulty in mapping susceptibility loci is the existence of considerable heterogeneity in the phenotype of PCa, with significant variation in clinical stage and grade of disease even among family members. To address this issue, we performed a genome-wide linkage scan on 71 informative families with two or more men with aggressive PCa. When only men with aggressive PCa were coded as affected, statistically significant evidence for linkage at chromosome 15q12 was detected (LOD=3.49; genome-wide p=0.005). Furthermore, the evidence for linkage increased when analyses were restricted to Caucasian-American pedigrees (n=65; LOD=4.05) and pedigrees with two confirmed aggressive cases (n=42, LOD=4.76). Interestingly, a 1-LOD support interval about our peak at 15q12 overl...Continue Reading

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Citations

Aug 26, 2006·Human Genetics·Daniel J SchaidUNKNOWN Investigators of the International Consortium for Prostate Cancer Genetics
May 1, 2012·Asian Journal of Andrology·William B Isaacs
Apr 9, 2013·Asian Journal of Andrology·Jianfeng XuS Lilly Zheng
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elaine A Ostrander, Miriam S Udler
Oct 16, 2007·BMC Medical Genetics·Joanne M MurabitoShih-Jen Hwang
May 4, 2011·The Prostate·Ethan M LangeKathleen A Cooney
Feb 15, 2007·The Prostate·G B ChristensenL A Cannon-Albright

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