Genome wide linkage study, using a 250K SNP map, of Plasmodium falciparum infection and mild malaria attack in a Senegalese population.

PloS One
Jacqueline MiletAndré Garcia

Abstract

Multiple factors are involved in the variability of host's response to P. falciparum infection, like the intensity and seasonality of malaria transmission, the virulence of parasite and host characteristics like age or genetic make-up. Although admitted nowadays, the involvement of host genetic factors remains unclear. Discordant results exist, even concerning the best-known malaria resistance genes that determine the structure or function of red blood cells. Here we report on a genome-wide linkage and association study for P. falciparum infection intensity and mild malaria attack among a Senegalese population of children and young adults from 2 to 18 years old. A high density single nucleotide polymorphisms (SNP) genome scan (Affimetrix GeneChip Human Mapping 250K-nsp) was performed for 626 individuals: i.e. 249 parents and 377 children out of the 504 ones included in the follow-up. The population belongs to a unique ethnic group and was closely followed-up during 3 years. Genome-wide linkage analyses were performed on four clinical and parasitological phenotypes and association analyses using the family based association tests (FBAT) method were carried out in regions previously linked to malaria phenotypes in literature and ...Continue Reading

References

Oct 1, 1992·European Journal of Immunology·C GouttefangeasA Bensussan
Aug 8, 1997·Biochemical and Biophysical Research Communications·S MinamotoT Kishimoto
Apr 16, 1998·American Journal of Human Genetics·R S Spielman, W J Ewens
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jul 11, 1998·The American Journal of Tropical Medicine and Hygiene·A GarciaL Abel
Jul 31, 1998·American Journal of Human Genetics·P RihetF Fumoux
Sep 15, 1998·Tropical Medicine & International Health : TM & IH·V RobertD Fontenille
Feb 5, 1999·Clinical and Experimental Immunology·J WattavidanageS Premawansa
Nov 4, 2000·American Journal of Human Genetics·S L LakeN M Laird
Apr 21, 2001·European Journal of Human Genetics : EJHG·S HorvathN M Laird
Aug 29, 2001·Bioinformatics·G R AbecasisL R Cardon
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Jan 17, 2002·The American Journal of Tropical Medicine and Hygiene·M NacherS Looareesuwan
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian C SchuttePaul B McCray
Jul 12, 2002·American Journal of Human Genetics·Pak C ShamGonçalo R Abecasis
Dec 7, 2002·Health Policy·Reginald Ikechukwu ChimaAnne Mills
Feb 4, 2003·Nature Reviews. Immunology·Hitoshi Kikutani, Atsushi Kumanogoh
Oct 31, 2003·Transactions of the Royal Society of Tropical Medicine and Hygiene·André SpiegelPierre Druilhe
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Mar 5, 2005·International Immunology·Isabelle Chabbert-de PonnatLaurence Boumsell
May 21, 2005·EMBO Reports·Ping ZhangWen-Ming Chu
Jun 4, 2005·Genes and Immunity·J N WilsonD Kwiatkowski
Jun 11, 2005·Bioinformatics·Janis E Wigginton, Gonçalo R Abecasis
Jun 18, 2005·The Journal of Infectious Diseases·F Ellis McKenzieChansuda Wongsrichanalai
Jul 8, 2005·American Journal of Human Genetics·Dominic P Kwiatkowski
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler

❮ Previous
Next ❯

Citations

May 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antoine RachasAndré Garcia
Jan 15, 2013·Journal of Tropical Medicine·Vitor R R de MendonçaManoel Barral-Netto
Apr 19, 2015·BMC Immunology·Audrey V GrantAnavaj Sakuntabhai
Mar 22, 2013·PloS One·Imen HammamiAndré Garcia
Dec 18, 2015·Memórias do Instituto Oswaldo Cruz·Vitor R de Mendonça, Manoel Barral-Netto
Nov 2, 2019·Human Genetics·Jacqueline MiletHervé Perdry
Feb 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Laura B ScheinfeldtSarah A Tishkoff
Mar 30, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hong Ming HuangGaetan Burgio

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
genotyping
PCR

Software Mentioned

SNPSpd
MERLIN
Pedstats
REGRESS
GRR
Affymetrix
Haploview

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
David CourtinAndré Garcia
© 2021 Meta ULC. All rights reserved