Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype

Clinical Sarcoma Research
Christian KoelscheAndreas von Deimling

Abstract

Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are lesions of the skin with overlapping histologic features and unspecific molecular traits. PDS behaves aggressive compared to AFX. Thus, a precise delineation, although challenging in some instances, is relevant. We examined the value of DNA-methylation profiling and copy number analysis for separating these tumors. DNA-methylation data were generated from 17 AFX and 15 PDS using the Illumina EPIC array. These were compared with DNA-methylation data generated from 196 tumors encompassing potential histologic mimics like cutaneous squamous carcinomas (cSCC; n = 19), basal cell carcinomas (n = 10), melanoma metastases originating from the skin (n = 11), leiomyosarcomas (n = 11), angiosarcomas of the skin and soft tissue (n = 11), malignant peripheral nerve sheath tumors (n = 19), dermatofibrosarcomas protuberans (n = 13), extraskeletal myxoid chondrosarcomas (n = 9), myxoid liposarcomas (n = 14), schwannomas (n = 10), neurofibromas (n = 21), alveolar (n = 19) and embryonal (n = 17) rhabdomyosarcomas as well as undifferentiated pleomorphic sarcomas (n = 12). DNA-methylation profiling did not separate AFX from PDS. The DNA-methylation profiles of the other cases...Continue Reading

References

May 8, 2007·Journal of Clinical Pathology·Cheryl BansalClay J Cockerell
Sep 3, 2011·Journal of Cutaneous Pathology·Dimas Suárez-VilelaJose Ramón Méndez-Alvarez
Oct 26, 2011·Journal of Surgical Oncology·John S Davidson, Daniel Demsey
May 18, 2013·International Journal of Dermatology·Lucinda S Liu, Oscar R Colegio
Aug 15, 2013·Current Opinion in Oncology·Andrew E Rosenberg
Sep 14, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Klaus G GriewankThomas Mentzel
Mar 13, 2014·Journal of Clinical Pathology·Johanne Lade-KellerTorben Steiniche
Apr 8, 2014·The American Journal of Surgical Pathology·Daisuke Nonaka, Paul W Bishop
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Stefan Kraft, Scott R Granter
Feb 10, 2016·Acta Neuropathologica·Manuel RöhrichDavid E Reuss
Feb 6, 2017·Dermatology and Therapy·Zoe ApallaXavier Castellsagué
Apr 5, 2017·Nature Reviews. Clinical Oncology·Jason J LukeGeorgina V Long
May 10, 2017·Surgical Pathology Clinics·Thomas MentzelThomas Brenn
Nov 4, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Klaus G GriewankThomas Mentzel
Nov 16, 2017·PloS One·Kevin LaiSarah T Arron
Jan 10, 2018·Oncotarget·Doris HelbigMichaela Angelika Ihle
Mar 15, 2018·Nature·David CapperStefan M Pfister
Mar 25, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christian KoelscheAndreas von Deimling

❮ Previous
Next ❯

Citations

Jul 4, 2020·Dermatologic Therapy·Alena BitelUwe Wollina
Aug 31, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M ZiemerE Dippel
Jun 26, 2020·Journal of Cutaneous Pathology·Anna Maria CesinaroMario Migaldi
Aug 7, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Olca BasturkDavid S Klimstra
Jan 18, 2020·Head and Neck Pathology·Thomas Brenn
Aug 21, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sebastian KleinDoris Helbig
Apr 23, 2021·The Journal of Molecular Diagnostics : JMD·Luca BerteroAndreas von Deimling
Jun 23, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ingrid FerreiraDavid J Adams
Jul 28, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christian KoelscheGunhild Mechtersheimer
Aug 13, 2021·Oncotarget·Nesrin M HasanNita Ahuja
Feb 1, 2022·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Doris HelbigStephan Grabbe

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
methylation profiling

Software Mentioned

R
package conumee

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.