Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Junichiro IrieWilliam M Ridgway

Abstract

NOD.Idd3/5 congenic mice have insulin-dependent diabetes (Idd) regions on chromosomes 1 (Idd5) and 3 (Idd3) derived from the nondiabetic strains B10 and B6, respectively. NOD.Idd3/5 mice are almost completely protected from type 1 diabetes (T1D) but the genes within Idd3 and Idd5 responsible for the disease-altering phenotype have been only partially characterized. To test the hypothesis that candidate Idd genes can be identified by differential gene expression between activated CD4+ T cells from the diabetes-susceptible NOD strain and the diabetes-resistant NOD.Idd3/5 congenic strain, genome-wide microarray expression analysis was performed using an empirical Bayes method. Remarkably, 16 of the 20 most differentially expressed genes were located in the introgressed regions on chromosomes 1 and 3, validating our initial hypothesis. The two genes with the greatest differential RNA expression on chromosome 1 were those encoding decay-accelerating factor (DAF, also known as CD55) and acyl-coenzyme A dehydrogenase, long chain, which are located in the Idd5.4 and Idd5.3 regions, respectively. Neither gene has been implicated previously in the pathogenesis of T1D. In the case of DAF, differential expression of mRNA was extended to th...Continue Reading

References

Jan 1, 1995·Annual Review of Immunology·L S WickerL B Peterson
May 26, 1995·Science·J D KatzD Mathis
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·A C PeaseS P Fodor
Sep 1, 1996·The Journal of Experimental Medicine·J HamannR A van Lier
May 1, 1997·Biochemical Society Transactions·L Adorini, S Trembleau
Jun 1, 1997·Research in Immunology·F S Wong, C A Janeway
May 29, 1998·European Journal of Immunology·J HamannR A van Lier
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S KoaradaW M Ridgway
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SogabeW C Song
May 11, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Feng LinM Edward Medof
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Syuichi KoaradaWilliam M Ridgway
Dec 4, 2002·Nature Genetics·Peter OlofssonRikard Holmdahl
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linda S WickerLaurence B Peterson
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kui LiuEdward K Wakeland
Feb 16, 2005·The Journal of Experimental Medicine·Jianuo LiuWen-Chao Song
Mar 18, 2005·Annual Review of Immunology·Mark S Anderson, Jeffrey A Bluestone
Oct 22, 2005·Nature Reviews. Immunology·Casey J FoxCraig B Thompson
Jun 20, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Alessandra C L CervinoNicholas F Tsinoremas
Feb 6, 2007·Nature Genetics·Jun YamanouchiPere Santamaria
May 29, 2007·Nature·Douglas F EastonBruce A J Ponder
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jun 21, 2007·Nature Immunology·William M RidgwayLinda S Wicker
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kara HunterLinda S Wicker

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Citations

May 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel B RainbowLinda S Wicker
Jul 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emma E Hamilton-WilliamsLinda A Sherman
Feb 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory J BerryHanspeter Waldner
Jan 15, 2016·Immunology and Cell Biology·Cini R JamesEmma E Hamilton-Williams
Jan 29, 2014·Molecular and Cellular Biology·Hemant K KiniStephen A Liebhaber
Oct 26, 2010·American Journal of Respiratory Cell and Molecular Biology·Martijn C NawijnAntoon J M Van Oosterhout
Oct 6, 2016·Diabetologia·Craig A BeamUNKNOWN Type 1 Diabetes TrialNet Study Group
Feb 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaotian LinLinda A Sherman

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