Mar 24, 2020

Flexible Representations of Odour Categories in the Mouse Olfactory Bulb

BioRxiv : the Preprint Server for Biology
E. KudryavitskayaADI MIZRAHI

Abstract

The ability to group sensory stimuli into categories is crucial for efficient interaction with a rich and ever-changing environment. In olfaction, basic features of categorical representation of odours were observed as early as in the olfactory bulb (OB). Categorical representation was described in mitral cells (MCs) as sudden transitions in responses to odours that were morphed along a continuum. However, it remains unclear to what extent such response dynamics actually reflects perceptual categories and decisions therein. Here, we tested the role of learning on category formation in the mouse OB, using in vivo two-photon calcium imaging and behaviour. We imaged MCs responses in naive mice and in awake behaving mice as they learned two tasks with different classification logic. In one task, a 1-decision boundary task, animals learned to classify odour mixtures based on the dominant compound in the mixtures. As expected, categorical representation of close by odours, which was evident already in naive animals, further increased following learning. In a second task, a multi-decision boundary task, animals learned to classify odours independent of their chemical similarity. Rather, odour discrimination was based on the meaning as...Continue Reading

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Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Genome-Wide Association Study
Size
EDN3 gene
Genome
Genes
Array-Based Comparative Genomic Hybridization
Genome Assembly Sequence
PRLR gene
Nucleic Acid Sequencing

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