Apr 16, 2020

GABA AND GLUTAMATE CHANGES IN PEDIATRIC MIGRAINE

BioRxiv : the Preprint Server for Biology
Tiffany K BellA. Harris

Abstract

Despite migraine being one of the top five most prevalent childhood diseases, a lack of knowledge about pediatric migraine limits effective treatment strategies; standard adult pharmaceutical therapies are less effective in children and can carry undesirable side-effects. Non-pharmacological therapies have shown some success in adults; however, to appropriately apply these in children we need to understand pediatric migraine's underlying biology. One theory is that migraine results from an imbalance in cortical excitability. Magnetic resonance spectroscopy (MRS) studies show changes in GABA and glutamate levels (the primary inhibitory and excitatory neurotransmitters in the brain, respectively) in multiple brain regions. Although there is indirect evidence of abnormal excitability in pediatric migraine, GABA and glutamate levels have yet to be assessed. The purpose of this study was to measure levels of GABA and glutamate in the thalamus, sensorimotor cortex and visual cortex of children with migraine using MRS. We found that children with migraine and aura had significantly lower glutamate levels in the visual cortex as compared to control children, opposite to results seen in adults. Additionally, we found significant correla...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Patterns
Genome
Transcription, Genetic
Reversal Learning
Genome Assembly Sequence
Promoter
Genes, Regulator
Encyclopedias
Genomics

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