Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming

Immunity
Laura L EloRiitta Lahesmaa

Abstract

Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.

References

Apr 18, 1996·Nature·K TakedaS Akira
Sep 13, 2000·The Journal of Biological Chemistry·Y Ohmori, T A Hamilton
Jul 18, 2002·The Journal of Biological Chemistry·Ryan P AndrewsGurjit K Khurana Hershey
Sep 21, 2004·Nature Immunology·Charalampos G Spilianakis, Richard A Flavell
Feb 16, 2005·International Immunology·Babita Agrawal, B Michael Longenecker
Oct 4, 2005·Molecular and Cellular Biology·April R SurianoKathleen E Sullivan
Dec 17, 2005·Nucleic Acids Research·Laura L EloTero Aittokallio
Jan 18, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Soon Ha KimN Sarvetnick
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shreevrat Goenka, Mark Boothby
Mar 17, 2006·Cytokine & Growth Factor Reviews·Daniel HebenstreitAlbert Duschl
Jun 20, 2006·Immunity·Casey T WeaverKenneth M Murphy
Sep 23, 2006·Nucleic Acids Research·Young-Ho Lee, Michael R Stallcup
Jun 2, 2007·Science·David S JohnsonBarbara Wold
Sep 4, 2007·Current Opinion in Immunology·Estelle BettelliVijay K Kuchroo
Jan 30, 2008·Bioinformatics·Ruiqiang LiJun Wang
Apr 1, 2008·The Journal of Biological Chemistry·Ryan BrunsingMaho Niwa
Apr 2, 2008·EMBO Reports·Charles E Massie, Ian G Mills
Aug 15, 2008·The Journal of Biological Chemistry·Ryo ShinnakasuToshinori Nakayama
Nov 4, 2008·Nature Biotechnology·Hongkai JiWing H Wong
Jan 9, 2009·European Journal of Immunology·Luis ArpaAntonio Celada
Apr 14, 2009·Current Opinion in Immunology·Adewole S AdamsonJohn J O'Shea
Dec 10, 2009·The Journal of Experimental Medicine·Shintaro KamizonoTak W Mak
Apr 28, 2010·The Journal of Experimental Medicine·Briana C BetzElizabeth J Taparowsky

❮ Previous
Next ❯

Citations

Mar 29, 2011·Immunologic Research·Shreevrat Goenka, Mark H Kaplan
Jul 25, 2012·Immunology and Cell Biology·Antonia L PritchardJohn W Upham
Mar 26, 2011·Nature Reviews. Immunology·John J O'SheaYuka Kanno
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marina MillerDavid H Broide
Jul 24, 2013·Briefings in Functional Genomics·Catherine M Evans, Richard G Jenner
Oct 10, 2013·Briefings in Functional Genomics·Tapio LönnbergRiitta Lahesmaa
Aug 11, 2011·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Akinori KanaiSumio Sugano
Oct 20, 2011·Nucleic Acids Research·Laura L EloTero Aittokallio
May 2, 2012·Cell Communication and Signaling : CCS·Christine Louis-Dit-SullyWolfgang W A Schamel
Dec 19, 2013·PloS One·Laura L Elo, Benno Schwikowski
Dec 10, 2013·BMC Genomics·Louise M BrignullAxel Nohturfft
Jul 31, 2013·Expert Review of Molecular Diagnostics·Maria M Esterhuyse, Stefan He Kaufmann
Jan 14, 2016·Genome Biology·Roser Vento-TormoEsteban Ballestar
Feb 3, 2012·Veterinary Immunology and Immunopathology·Fabienne Girard-MisguichFrançois Meurens
Oct 9, 2012·European Journal of Immunology·Elisabeth MaierJutta Horejs-Hoeck
Feb 15, 2013·Immunological Reviews·Golnaz VahediKiyoshi Hirahara
Apr 21, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A H PoonQ Hamid
Feb 26, 2013·European Journal of Immunology·Henk-Jan van den HamArno C Andeweg
Aug 16, 2014·Immunological Reviews·Subhash K Tripathi, Riitta Lahesmaa
Nov 22, 2015·Genome Medicine·Kartiek KanduriRiitta Lahesmaa
Mar 31, 2015·Cytokine·Stephen A RedpathGeorgia Perona-Wright
Jan 15, 2014·JAK-STAT·Hannah H Walford, Taylor A Doherty
Sep 17, 2011·Transcription·Gretta L Stritesky, Mark H Kaplan
Sep 24, 2013·JAK-STAT·Thomas WeimbsJeffrey J Talbot
Nov 20, 2013·Seminars in Immunology·Soile Tuomela, Riitta Lahesmaa
Jan 22, 2013·Cell·Renato OstuniGioacchino Natoli
Mar 3, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiao-Lei HuangJing Wang
May 25, 2016·Clinical Reviews in Allergy & Immunology·Aleš GoropevšekTadej Avčin
Oct 22, 2016·Biochimica Et Biophysica Acta·Nathalie Dehne, Bernhard Brüne
Nov 12, 2016·Seminars in Immunopathology·Mark H Kaplan
Jan 10, 2017·Nature Communications·Kazuhiko YamamuraYoshinori Fukui

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.