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Genome-wide reconstruction of complex structural variants using read clouds

Nature Methods

Jul 18, 2017

Noah SpiesArend Sidow

Abstract

In read cloud approaches, microfluidic partitioning of long genomic DNA fragments and barcoding of shorter fragments derived from these fragments retains long-range information in short sequencing reads. This combination of short reads with long-range information represents a powerful a...read more

Mentioned in this Paper

Genome-Wide Association Study
Sarcoma
Genome
Reconstructive Surgical Procedures
Synaptic Vesicles
Nucleic Acid Sequencing
Single Molecule Imaging
Genome Mapping
Genomics
Sequencing
29
1
103
Paper Details
References
  • References22
  • Citations15
123
  • References22
  • Citations15
12

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Genome-wide reconstruction of complex structural variants using read clouds

Nature Methods

Jul 18, 2017

Noah SpiesArend Sidow

PMID: 28714986

DOI: 10.1038/nmeth.4366

Abstract

In read cloud approaches, microfluidic partitioning of long genomic DNA fragments and barcoding of shorter fragments derived from these fragments retains long-range information in short sequencing reads. This combination of short reads with long-range information represents a powerful a...read more

Mentioned in this Paper

Genome-Wide Association Study
Sarcoma
Genome
Reconstructive Surgical Procedures
Synaptic Vesicles
Nucleic Acid Sequencing
Single Molecule Imaging
Genome Mapping
Genomics
Sequencing
29
1
103

Feeds With Similar Papers

Molecular Organization of Synapses

This feed focuses on the molecular organization of synapses between two nerve cells, synaptic signal transduction, and synaptic vesicles. Here is the latest research on organization of synapses.

Related Papers

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology

Challenges in studying genomic structural variant formation mechanisms: the short-read dilemma and beyond

BioEssays : News and Reviews in Molecular, Cellular and Developmental BiologyOctober 1, 2011
Megumi Onishi-Seebacher, Jan O Korbel
Paper Details
References
  • References22
  • Citations15
123
  • References22
  • Citations15
12

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