Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae

Molecular and Cellular Biology
Melissa Durant, B Franklin Pugh

Abstract

Histone acetylation regulates gene expression, yet the functional contributions of the numerous histone acetyltransferases (HATs) to gene expression and their relationships with each other remain largely unexplored. The central role of the putative HAT-containing TAF1 subunit of TFIID in gene expression raises the fundamental question as to what extent, if any, TAF1 contributes to acetylation in vivo and to what extent it is redundant with other HATs. Our findings herein do not support the basic tenet that TAF1 is a major HAT in Saccharomyces cerevisiae, nor do we find that TAF1 is functionally redundant with other HATs, including Gcn5, Elp3, Hat1, Hpa2, Sas3, and Esa1, which is in contrast to previous conclusions regarding Gcn5. Our findings do reveal that of these HATs, only Gcn5 and Esa1 contribute substantially to gene expression genome wide. Interestingly, histone acetylation at promoter regions throughout the genome does not require TAF1 or RNA polymerase II, indicating that most acetylation is likely to precede transcription and not depend upon it. TAF1 function has been linked to Bdf1, which binds TFIID and acetylated histone H4 tails, but no linkage between TAF1 and the H4 HAT Esa1 has been established. Here, we presen...Continue Reading

References

May 1, 1987·Molecular and Cellular Biology·M NonetR Young
Sep 12, 1996·Nature·S S WalkerM R Green
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Dec 9, 1998·Cell·F C HolstegeR A Young
Mar 19, 1999·Molecular and Cellular Biology·A S ClarkeL Pillus
Jan 29, 2000·Molecular and Cellular Biology·E L DunphyE H Wang
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·D E Sterner, S L Berger
Dec 2, 2000·Nature·M VogelauerM Grunstein
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·G Sebastiaan WinklerJesper Q Svejstrup
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bradley E BernsteinStuart L Schreiber
Nov 7, 2002·Molecular Cell·Carmelata ChitikilaB Franklin Pugh
Nov 7, 2002·Molecular Cell·Arnold KristjuhanJesper Q Svejstrup
Mar 7, 2003·Molecular Cell·Oranart Matangkasombut, Stephen Buratowski
Mar 11, 2003·The Journal of Biological Chemistry·Ann SuttonRolf Sternglanz
Jun 5, 2003·Genes & Development·Alexandre A BoudreaultJacques Côté
Jun 13, 2003·Trends in Genetics : TIG·Michael J CarrozzaJacques Côté
Dec 24, 2003·Molecular Cell·Nevan J KroganJack F Greenblatt
Mar 10, 2004·Cell·Andrew D BasehoarB Franklin Pugh
Jun 9, 2004·Trends in Cell Biology·Alejandra Loyola, Genevieve Almouzni
Jun 10, 2004·Cell·Siavash K KurdistaniMichael Grunstein
Jul 23, 2004·Current Biology : CB·Craig L Peterson, Marc-André Laniel
Oct 1, 2004·The EMBO Journal·Arnold Kristjuhan, Jesper Q Svejstrup
Oct 21, 2004·Molecular Cell·François RobertRichard A Young
Nov 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sara J Zanton, B Franklin Pugh
Mar 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael F DionOliver J Rando

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Citations

Feb 6, 2007·Biochemistry·Christopher E BerndsenJohn M Denu
Apr 29, 2008·Nucleic Acids Research·Tatsuki KunohTomohiro Matsumoto
May 2, 2009·Nucleic Acids Research·R Magnus N FriisMichael C Schultz
May 29, 2007·Molecular and Cellular Biology·Melissa Durant, B Franklin Pugh
Oct 14, 2009·Molecular and Cellular Biology·Daniel S GinsburgAlan G Hinnebusch
Nov 1, 2006·Molecular and Cellular Biology·Krassimira A GarbettP Anthony Weil
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shannon R Uffenbeck, Jocelyn E Krebs
Jul 31, 2012·BMC Genomics·Djordje Bajić, Juan F Poyatos
Jun 23, 2007·Genome Biology·Lorena E RosalenyVicente Tordera
Feb 5, 2008·Genetics·Peter V DeckerM Mitchell Smith
Sep 25, 2010·Seminars in Immunology·Ramesh Subrahmanyam, Ranjan Sen
Mar 6, 2007·Mutation Research·Jeremy A Daniel, Patrick A Grant
Mar 31, 2007·Biochimica Et Biophysica Acta·Joke J F A van VugtColin Logie
Mar 11, 2015·Protein Science : a Publication of the Protein Society·Nha-Thi Nguyen-HuynhEmmanuelle Leize-Wagner
Apr 7, 2010·Current Opinion in Cell Biology·Evangelia KoutelouSharon Y R Dent
Oct 24, 2007·International Journal for Parasitology·Lakshminarayan M IyerL Aravind
Sep 22, 2012·Biophysical Journal·Anne SchwabeFrank J Bruggeman
Jul 2, 2016·International Journal of Molecular Sciences·Abu Iftiaf Md Salah Ud-DinAnna Roujeinikova
Feb 13, 2016·Microbiology and Molecular Biology Reviews : MMBR·Monika SchmollAlfredo Herrera-Estrella
Jan 30, 2008·Nature Genetics·Jung Kyoon Choi, Young-Joon Kim
Sep 13, 2019·Epigenetics : Official Journal of the DNA Methylation Society·María E Pérez-MartínezVicente Tordera
Jul 22, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keisuke WagatsumaKoichi Ikuta
Mar 20, 2019·Nature Reviews. Genetics·Paul B TalbertSteven Henikoff
Jul 17, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·H Th Marc Timmers
Jan 13, 2021·Nature Communications·Benjamin J E MartinLeAnn J Howe
Mar 31, 2021·Annual Review of Genomics and Human Genetics·Paul B Talbert, Steven Henikoff

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