Genome wide response to dietary tetradecylthioacetic acid supplementation in the heart of Atlantic Salmon (Salmo salar L).

BMC Genomics
F GrammesH Takle

Abstract

Under-dimensioned hearts causing functional problems are associated with higher mortality rates in intensive Atlantic salmon aquaculture. Previous studies have indicated that tetradecylthioacetic acid (TTA) induces cardiac growth and also stimulates transcription of peroxisome proliferator activated receptors (PPAR) αand βin the Atlantic salmon heart. Since cardiac and transcriptional responses to feed are of high interest in aquaculture, the objective of this study was to characterize the transcriptional mechanisms induced by TTA in the heart of Atlantic salmon. Atlantic salmon were kept at sea for 17 weeks. During the first 8 weeks the fish received a TTA supplemented diet. Using microarrays, profound transcriptional effects were observed in the heart at the end of the experiment, 9 weeks after the feeding of TTA stopped. Approximately 90% of the significant genes were expressed higher in the TTA group. Hypergeometric testing revealed the over-representation of 35 gene ontology terms in the TTA fed group. The GO terms were generally categorized into cardiac performance, lipid catabolism, glycolysis and TCA cycle. Our results indicate that TTA has profound effects on cardiac performance based on results from microarray and qRT...Continue Reading

References

Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
Jul 7, 2000·Developmental Biology·V M ChristoffelsA F Moorman
Nov 23, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G ChinettiB Staels
May 12, 2001·The Journal of Investigative Dermatology·I M FreedbergM Blumenberg
May 12, 2001·The Journal of Investigative Dermatology·M WestergaardK Kristiansen
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·K FellenbergM Vingron
Jan 10, 2002·The Journal of Clinical Investigation·Brian N FinckDaniel P Kelly
Jun 5, 2002·Current Opinion in Lipidology·Rolf K BergeHans Grav
Dec 31, 2002·Cardiovascular Research·Konrad F FrankRobert H G Schwinger
Mar 26, 2003·Cardiovascular Research·Robert H G SchwingerKeld Kjeldsen
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Jan 23, 2004·Diseases of Aquatic Organisms·Trygve T PoppeBrit Tørud
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Dec 8, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Corina Moya-FalcónBente Ruyter
Mar 31, 2005·Bioinformatics·Aedín C CulhaneDesmond G Higgins
Apr 30, 2005·Trends in Pharmacological Sciences·Joel P BergerPeter T Meinke
Sep 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Nandakumar SambandamGary D Lopaschuk
Nov 19, 2005·BMC Molecular Biology·Pål A OlsvikIvar Hordvik
Feb 14, 2006·The Journal of Biological Chemistry·Jian XuJeffery D Molkentin
Apr 7, 2006·Journal of Cell Science·Ryan J Hoefen, Bradford C Berk
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Sep 15, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ellen Johanne KlevelandTor Gjøen
Oct 3, 2006·Cardiovascular Research·Brian N Finck
Nov 14, 2006·Bioinformatics·S Falcon, R Gentleman
May 29, 2007·Nucleic Acids Research·Yuki MoriyaMinoru Kanehisa
Jun 19, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Tor GjøenBente Ruyter
Nov 27, 2007·The Journal of Clinical Investigation·Eileen M BurkartDaniel P Kelly
Aug 5, 2008·Cell·Vihang A NarkarRonald M Evans
Jul 8, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Aleksei KrasnovSven Martin Jørgensen

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Datasets Mentioned

BETA
GSE25305

Methods Mentioned

BETA
biopsies
chips
Feature Extraction
PCR

Software Mentioned

KAAS
Feature Extraction (
Feature Extraction
R
GOstats
R package lattice /
limma
latticeExtra
BlastX
Bioconductor

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