Abstract
Alternative transcripts of protein kinases and protein phosphatases are known to encode peptides with altered substrate affinities, subcellular localizations, and activities. We undertook a systematic study to catalog the variant transcripts of every protein kinase-like and phosphatase-like locus of mouse http://variant.imb.uq.edu.au. By reviewing all available transcript evidence, we found that at least 75% of kinase and phosphatase loci in mouse generate alternative splice forms, and that 44% of these loci have well supported alternative 5' exons. In a further analysis of full-length cDNAs, we identified 69% of loci as generating more than one peptide isoform. The 1,469 peptide isoforms generated from these loci correspond to 1,080 unique Interpro domain combinations, many of which lack catalytic or interaction domains. We also report on the existence of likely dominant negative forms for many of the receptor kinases and phosphatases, including some 26 secreted decoys (seven known and 19 novel: Alk, Csf1r, Egfr, Epha1, 3, 5,7 and 10, Ephb1, Flt1, Flt3, Insr, Insrr, Kdr, Met, Ptk7, Ptprc, Ptprd, Ptprg, Ptprl, Ptprn, Ptprn2, Ptpro, Ptprr, Ptprs, and Ptprz1) and 13 transmembrane forms (four known and nine novel: Axl, Bmpr1a, Csf...Continue Reading
References
Jul 1, 1992·Developmental Biology·P RossiV Sorrentino
May 18, 1990·Cell·R KleinM Barbacid
Feb 28, 1989·Biochemical and Biophysical Research Communications·S Seino, G I Bell
Dec 8, 1995·The Journal of Biological Chemistry·S KumarP R Young
Nov 10, 1995·The Journal of Biological Chemistry·F J PixleyE R Stanley
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R L Kendall, K A Thomas
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·A Elson, P Leder
Aug 16, 1996·Science·J XingM E Greenberg
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·E LeviI Vlodavsky
Oct 25, 1996·The Journal of Biological Chemistry·S KamatkarG Swarup
Nov 1, 1996·Genomics·P CarninciC Schneider
Dec 17, 1996·Biochemistry·J ZhangR A Anderson
Feb 14, 1998·The Journal of Biological Chemistry·C E ChalfantD R Cooper
Jul 17, 1998·Developmental Genetics·P KettunenI Thesleff
Nov 5, 1998·The Journal of Comparative Neurology·B MennF Lamballe
Jul 27, 1999·The Journal of Biological Chemistry·A MartinF W Tsui
Oct 26, 1999·Journal of Neuroscience Research·H A BurgessO Reiner
Jun 3, 2000·Nature Biotechnology·S BrennerK Corcoran
Jun 10, 2000·Molecular and Cellular Biology·A YuryevL P Wennogle
Oct 6, 2000·Genes & Development·P KomarnitskyS Buratowski
Nov 23, 2000·Nature·J HolmbergJ Frisén
Dec 15, 2000·Genes & Development·S J Nowak, V G Corces
Jan 15, 2001·The Journal of Biological Chemistry·C YanB C Berk
Jan 12, 2001·Journal of Molecular Biology·A KroghE L Sonnhammer
Feb 13, 2001·Genomics·J L ReiterN J Maihle
Feb 13, 2001·Biochemical and Biophysical Research Communications·A HaapasaloE Castrén
Feb 22, 2001·Science·J C VenterX Zhu
Apr 18, 2001·The Journal of Biological Chemistry·Z QianM R Rosner
May 22, 2001·Oncogene·A AignerF Czubayko
Jul 4, 2001·Nucleic Acids Research·B ModrekC Lee
Jul 27, 2001·The Journal of Biological Chemistry·Y S NiinoT Kuroki
Jul 27, 2001·The Journal of Biological Chemistry·H A Burgess, O Reiner
Oct 19, 2001·Biochemical and Biophysical Research Communications·E A GrzybowskaJ A Siedlecki
Dec 26, 2001·Nature Genetics·Barmak Modrek, Christopher Lee
May 23, 2002·Current Opinion in Chemical Biology·Gavin C Roberts, Christopher W J Smith
Aug 31, 2002·Nucleic Acids Research·Qiang XuChristopher Lee
Sep 28, 2002·Human Molecular Genetics·Stefan Stamm
Oct 9, 2002·Genome Research·Lincoln D SteinSuzanna Lewis
Dec 5, 2002·The Journal of Biological Chemistry·Veronique RousseauJean-Vianney Barnier
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Dec 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Benjamin P LewisSteven E Brenner
Jan 10, 2003·Nucleic Acids Research·Judith A BlakeUNKNOWN Mouse Genome Database Group
Mar 4, 2003·Molecular and Cellular Biology·Jocelyn H WrightBahija Jallal
Mar 5, 2003·Trends in Genetics : TIG·Evgenia V KriventsevaShamil Sunyaev
Apr 22, 2003·Methods in Molecular Biology·Yutaka Suzuki, Sumio Sugano
May 9, 2003·Nucleic Acids Research·T A ThanarajJuha Muilu
Jun 24, 2003·Genome Research·Timothy RavasiUNKNOWN GSL Members
Jun 24, 2003·Genome Research·Alistair R R ForrestUNKNOWN GSL Members
Jun 24, 2003·Genome Research·Masaaki FurunoYasushi Okazaki
Oct 30, 2003·The Journal of Biological Chemistry·Scott J CameronJay Yang
Citations
May 21, 2011·Genome Research·Mutsumi Kanamori-KatayamaYoshihide Hayashizaki
Nov 2, 2011·Genome Research·Gabriel KolleSean M Grimmond
Aug 7, 2007·Cytogenetic and Genome Research·H TangS J Hubbard
Dec 24, 2009·BMC Genomics·Krishanpal AnamikaNarayanaswamy Srinivasan
Nov 13, 2008·BMC Cancer·Sebastian KorffJohannes Gebert
Apr 21, 2009·Genome Biology·Jessica SeverinAlistair Rr Forrest
Sep 5, 2008·PLoS Computational Biology·Mark A RaganBruce Ross
May 10, 2006·PLoS Genetics·Yoshihide Hayashizaki, Piero Carninci
Aug 21, 2008·PloS One·Charles PlessyPiero Carninci
Oct 28, 2008·PloS One·Hugues DardenteDavid G Hazlerigg
Jul 18, 2009·Comparative and Functional Genomics·David TalaveraXavier de la Cruz
Dec 12, 2012·Blood·Jan AstermarkUNKNOWN Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort
Jan 17, 2019·Annals of the New York Academy of Sciences·George R Uhl, Maria J Martinez
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Nurhan OzluJudith A J Steen
Aug 2, 2017·Clinical Science·Rocio RojoDavid A Hume
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·David A Hume
Feb 1, 2011·British Journal of Haematology·Ellen R McPhailBrian P O'Neill
Jun 24, 2015·The Journal of Physical Chemistry. B·Marta WiśniewskaMariusz Makowski
Aug 5, 2008·Neuroscience·N C H KerrD Wynick
Jul 25, 2007·Chemical Reviews·Irena I Artamonova, Mikhail S Gelfand
Sep 3, 2010·Science Signaling·Yutaka Arimura, Junji Yagi
Nov 6, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kristin A MarksRobin E Duncan